Adults
With uncomplicated removal of the teeth of the upper jaw, in the absence of inflammation, 1.7 ml of the drug (per tooth) is usually injected into the submucosa in the region of the transitional fold from the vestibular side.
In some cases, additional administration of 1 to 1.7 ml of the drug may be required to achieve complete anesthesia. In most cases, there is no need to perform painful injections on the palatine side. For anesthesia with palatine incisions and suturing with the goal of creating a palatine depot, about 0.1 ml of the drug per shot is needed. When several adjacent teeth are removed, the number of injections is usually limited. In the case of removal of premolars of the lower jaw in the absence of inflammation, you can do without mandibular anesthesia. infiltration anesthesia, provided by injection of 1.7 ml per tooth, is usually sufficient. If this method fails to achieve the desired effect, an additional injection of 1-1.7 ml of the drug into the submucosa should be performed in the region of the transitional fold of the lower jaw from the vestibular side. If, however, in this case, it was not possible to achieve complete anesthesia, it is necessary to blockade the mandibular nerve. To prepare the cavity of the tooth for sealing or treatment for the crown of any tooth, with the exception of lower molars, the administration of the drug in a dose of 0.5 to 1.7 ml per tooth by typeinfiltration anesthesia from the vestibular side. The exact amount depends on the desired depth and duration of the procedure.
When performing one treatment procedure, adults can administer up to 7 mg of articaine per 1 kg of body weight.
Duration Intrapulpic anesthesia is not less than 45 minutes, the duration of anesthesia of soft tissues is from 120 to 240 minutes.
Elderly patients
An increase in the concentration of the drug in the blood plasma can be caused by a decrease in metabolic processes and a decrease in the volume of distribution. In particular, the risk of cumulation of the drug increases after repeated administration. It is required to reduce the dose for diseases of the heart and liver.
Patients with hepatic insufficiency
Articaine is metabolized by the liver. A dose reduction may be required to achieve sufficient depth of anesthesia and systemic accumulation.
Patients with renal insufficiency
Basically articaine and its metabolites are excreted in the urine. A dose reduction may be required to achieve sufficient depth of anesthesia and systemic accumulation.
Dose reduction is required for angina pectoris, atherosclerosis and other diseases listed in the "With caution" section.
Children (from 4 years to 18 years)
In patients of child age (over 4 years) the dose of the drug is selected depending on the age and body weight of the child. The recommended dose of the drug depends on the body weight:
| Body mass | Recommended dose |
| articaine / mg / child | drug / ml / child |
| 20-<30 | 10-40 | 0.25 ml - 1 ml |
| 30-<40 | 20-80 | 0.5 ml - 2 ml |
| 40-<45 |
Do not exceed the dose equivalent to 7 mg of articaine / kg body weight! Maximum recommended doses for children:
| Body weight (kg) (corresponds to the age groups of children according to ± norms of growth tables) | The maximum permitted dose at the rate of 7 mg / kg body weight |
| articaine mg / child | a drug ml / child |
| 20- <30 | 140 | 3,5 |
| 30- <40 | 210 | 5,25 |
| 40- <45 | 280 | 7,0 |
| 45 - <50 | 315 | 7,9 |
| 50-<60 | 350 | 8,7 |
| 60-<70 | 420 | 10,5 |
| 70 - <80 | 490 | 12,2 |
Due to articaine rapidly diffuses into tissues and bone tissue density in children is lower compared to adults, infiltrative anesthesia may be used for children instead of conductive anesthesia.