The development of systemic symptoms of overdose is possible with the accidental or deliberate taking of the drug inside or exceeding the dosage with topical application.
Symptoms: dilated pupil, nausea, cyanosis, fever, convulsions, arrhythmias, hypertension, pulmonary edema, dyspnea. Excessive systemic absorption of imidazole derivatives can lead to CNS depression, with drowsiness, hypothermia, bradycardia, collapse, apnea and coma.
The risk of overdose symptoms associated with drug absorption is high in young children, especially if swallowed. An overdose in children may be manifested by depression of the central nervous system, accompanied by drowsiness, excessive sweating, severe hypotension, including shock.
Treatment: The specific antidote is unknown. Assign Activated carbon, gastric lavage, inhalation of oxygen, use of antipyretic, anticonvulsants.To reduce blood pressure apply phentolamine 5 mg on a 0.9% solution NaCl slowly in / in or 100 mg orally.