Active substanceTetrisolinTetrisolin
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  • Dosage form: & nbspeye drops
    Composition:

    1 ml of the preparation contains:

    Active ingredient: tetrisoline hydrochloride - 0.5 mg;

    Auxiliary components: boric acid, sodium tetraborate decahydrate, disodium edetate dihydrate, benzalkonium chloride, purified water.

    Description:A clear, colorless solution.
    Pharmacotherapeutic group:Alpha - adrenomimetic
    ATX: & nbsp

    S.01.G.A.02   Tetrisolin

    Pharmacodynamics:

    Alpha-adrenostimulant, it has vasoconstrictive and anti-edematous action. With topical application reduces the swelling of the conjunctiva, burning sensations, soreness of the mucous membrane of the eyes, lacrimation. The vasoconstrictor effect develops within a few minutes and persists for 4-8 hours.

    Pharmacokinetics:With topical application, systemic absorption is low.
    Indications:

    - moderate eye irritation: pruritus, edema and conjunctival hyperemia, burning, lacrimation, injected sclera due to chemical and physical factors (dust, cosmetics, swimming in chlorinated water, the action of bright light or the radiation of a computer monitor);

    - allergic conjunctivitis.

    Contraindications:

    Hypersensitivity to the drug components, glaucoma, endothelial-epithelial dystrophy of the cornea, children's age (up to 3 years), acute cardiovascular insufficiency, bacterial infection of the eye, foreign body of the eye

    Carefully:

    Arterial hypertension, arrhythmias, aneurysm, hyperthyroidism, pheochromocytoma, diabetes mellitus, severe organic diseases of the heart and blood vessels (including coronary heart disease (CHD), treatment with MAO inhibitors and other drugs that increase blood pressure (BP), diabetes mellitus.

    Pregnancy and lactation:

    Application in pregnancy and lactation is possible only if the intended benefit exceeds the risk for the mother or child.

    Dosing and Administration:

    Locally. Adults and children over 3 years old, in each eye in the lower conjunctival sac - 1-2 drops 2-3 times a day.

    If the improvement does not occur within 48 hours, further reception should be discontinued and consult a doctor.

    Side effects:

    Local: increased intraocular pressure, burning sensation and reactive hyperemia of the eye, rarely - dilated pupil.

    System: increased blood pressure, hyperglycemia, cardiac dysfunction, headache, nausea, drowsiness, weakness, tremor, dizziness, insomnia, tachycardia, allergic reactions.

    Overdose:

    The development of systemic symptoms of overdose is possible with the accidental or deliberate taking of the drug inside or exceeding the dosage with topical application.

    Symptoms: dilated pupil, nausea, cyanosis, fever, convulsions, arrhythmias, hypertension, pulmonary edema, dyspnea. Excessive systemic absorption of imidazole derivatives can lead to CNS depression, with drowsiness, hypothermia, bradycardia, collapse, apnea and coma.

    The risk of overdose symptoms associated with drug absorption is high in young children, especially if swallowed. An overdose in children may be manifested by depression of the central nervous system, accompanied by drowsiness, excessive sweating, severe hypotension, including shock.

    Treatment: The specific antidote is unknown. Assign Activated carbon, gastric lavage, inhalation of oxygen, use of antipyretic, anticonvulsants.To reduce blood pressure apply phentolamine 5 mg on a 0.9% solution NaCl slowly in / in or 100 mg orally.

    Interaction:

    The drug should not be used simultaneously with MAO inhibitors (phenelzine, nialamide, iproniazid, etc.) and within 10 days after discontinuation of their intake.

    Simultaneous use with monoamine oxidase inhibitors, tricyclic antidepressants, guanethidine can cause hypertension, tachycardia.

    Simultaneous use with resepin, insulin, propranolol, general anesthetics, atropine increases the risk of cardiovascular effects of tetrizoline.

    Simultaneous application with guanethidine can provoke mydriasis (dilated pupil), with a temporary visual impairment.

    Special instructions:
    Tetrizolin in the form of eye drops is advisable to use only with mild irritation of the eyes. If irritation and congestion hyperemia is associated with an infectious disease, the presence of a foreign body or a chemical injury to the cornea, an ophthalmologist must be consulted.
    If within 48 hours after the onset of the use of eye drops the symptoms of the disease persist, become more pronounced, or a side effect occurs, discontinue use of the drug and consult with the oculist.

    If there is intense pain in the eyes, headache, visual impairment, sudden appearance of "floating spots" before the eyes, redness of the eyes, pain when exposed to light or doubling in the eyes, you should immediately consult a doctor.

    When wearing contact lenses, they are removed before instillation of the drug and reestablished 15 minutes after it. Avoid direct contact of eye drops with soft contact lenses due to possible disruption of their transparency.

    Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased concentration of attention, rapidity of psychomotor reactions and good vision (after the application of eye drops, pupil dilating and blurring of vision may be possible).
    Form release / dosage:

    Eye drops 0.05%.

    Packaging:For 15 ml of solution in a white polymer bottle-dropper closed with a polymer cover with a safety ring. One bottle-dropper along with instructions for use in a cardboard pack.
    Storage conditions:

    Store at 15-25 ° C in the original packaging.

    Keep out of the reach of children.

    Shelf life:

    5 years. After opening the bottle, the drops should be used within 4 weeks.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-007079/08
    Date of registration:04.09.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:K.O. Ромфарм Компани С.Р.Л.K.O. Ромфарм Компани С.Р.Л. Romania
    Manufacturer: & nbsp
    Representation: & nbspРомфарма ОООРомфарма ООО
    Information update date: & nbsp13.02.2017
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