Tetrizolin - instructions for use, doses, side effects, contraindications

Excites alpha-adrenergic receptors. With topical application in the form of eye drops reduces the swelling of the conjunctiva, a burning sensation, irritation, itching, soreness of the eye mucosa, lacrimation.

When used in the form of nasal drops causes narrowing of small arterioles of nasal passages, reduces edema of the nasal mucosa and reduces secretion.

Pharmacokinetics:

After topical application, the effect develops after 1 minute and lasts 4-8 hours. When topical application is practically not absorbed, one can not exclude systemic absorption of the drug in patients with damage to the mucous membrane and epithelium. With systemic absorption, the development of hypertension is possible.

Indications:

Edema of the conjunctiva, secondary hyperemia in allergic eye diseases, irritation of the conjunctiva (as a result of exposure to chemical and physical factors, including smoke, dust,chlorinated water, bright light, cosmetics, contact lenses), catarrhal conjunctivitis.

Edema of the mucous membrane of the nasal cavity in patients suffering from rhinitis, pharyngitis, sinusitis, pollinosis, as well as to reduce the edema of the nasal mucosa in need of diagnostic and therapeutic measures.

ICD-10

VII.H10-H13.H10.4 Chronic conjunctivitis

VII.H10-H13.H10.2 Other acute conjunctivitis

VII.H10-H13.H10.1 Acute atopic conjunctivitis

X.J00-J06.J02.9 Acute pharyngitis, unspecified

X.J00-J06.J01.9 Acute sinusitis, unspecified

X.J00-J06.J00 Acute nasopharyngitis (runny nose)

X.J30-J39.J30.3 Other allergic rhinitis

X.J30-J39.J30.1 Allergic rhinitis caused by pollen of plants

X.J30-J39.J30 Vasomotor and allergic rhinitis

XIX.S00-S09.S05 Injury of the eye and orbit

VII.H55-H59.H57.1 Eye Pain

VII.H10-H13.H10.5 Blepharoconjunctivitis

VII.H15-H22.H16.2 Keratoconjunctivitis

XVIII.R50-R69.R60.0 Localized edema

XIX.T66-T78.T78.4 Allergy, unspecified

Contraindications:

Hypersensitivity; eye drops: severe eye diseases (glaucoma, dry eye syndrome, epithelial-endothelial dystrophy of the cornea), children under 2 years; drops in the nose: dry rhinitis, children under 2 years old (0.05% solution), up to 6 years (0.1% solution).

Carefully:

Severe cardiovascular diseases (including IHD, arrhythmia, cardiac aneurysm, arterial hypertension), hyperthyroidism, diabetes mellitus, pheochromocytoma, the period of treatment with drugs that raise blood pressure, including MAO inhibitors; pregnancy, breast-feeding.

Tetrizolin in the form of eye drops is advisable to use only with mild irritation of the eyes. If irritation and congestion hyperemia is associated with an infectious disease, the presence of a foreign body or a chemical injury to the cornea, an ophthalmologist must be consulted.

Pregnancy and lactation:

Category of recommendations FDA is not defined. Adequate and well-controlled studies in humans and animals have not been conducted.

In view of the likelihood of systemic side effects, use during pregnancy and breastfeeding is possible only after a careful comparison of the possible benefits for the mother and the risk to the fetus or child.

Reproductive studies in animals have not been conducted. It is not known whether the blood is excreted tetrisolin in breast milk. Use with caution!

Dosing and Administration:

Conjunctival, in each eye in the lower conjunctival sac - 1-2 drops 2-3 times a day. Without consultation, the oculist should not be used continuously for more than 4 days. If the improvement does not occur within 48 hours, treatment should be discontinued.

Intranasally, adults and children over 6 years of age - 2-4 drops 0.1% solution, children 2-6 years - 2-3 drops of 0,05% solution in each nasal passage with an interval of at least 3 hours. You can not use more 3-5 days (except for doctor's recommendations). Re-appointment is possible only after a few days.

Side effects:

Eye drops: enlargement of the pupil, increased intraocular pressure, burning sensation and reactive hyperemia of the eye.

Nasal drops: burning and tingling in the nose, sneezing, dryness of the nasal mucosa; with prolonged use or exceeding the dose - secondary edema, hyperemia of the mucous membrane of the nasal cavity.

System Effects: headache, dizziness, weakness, tremor, insomnia, increased blood pressure, palpitations, nausea, hyperglycemia, allergic reactions.

Overdose:

Symptoms: dilated pupil, nausea, cyanosis, fever, convulsions, tachycardia or bradycardia, hypertension, dizziness, a shock-like syndrome with hypotension and bradycardia.An overdose in children may be manifested by depression of the central nervous system, accompanied by drowsiness, excessive sweating, severe hypotension, including shock.

Treatment: purpose of activated carbon, gastric lavage, symptomatic therapy (inhalation of oxygen, use of antipyretic, anticonvulsants). The specific antidote is unknown.

Interaction:

Incompatible with MAO inhibitors (possibly development of hypertension).

Special instructions:

It is necessary to strictly follow the dosing regimen. Avoid prolonged use and overdose. With prolonged use, it is possible to develop toxic effects. The risk of overdose due to systemic absorption of the drug is high in newborns and young children (especially if accidentally swallowed).

If, within 48 hours after the onset of the use of eye drops, the symptoms of the disease persist or become more pronounced, or if there is a side effect, discontinue use of the drug and consult an oculist. When there is intense pain in the eyes, headache, visual impairment, the sudden appearance of floating spots in front of the eyes, redness of the eyes,pain when exposed to light or doubling in the eyes, you must immediately consult a doctor.

When wearing contact lenses, they are removed before instillation of the drug and reestablished 15 minutes after it. Avoid direct contact of eye drops with soft contact lenses due to possible disruption of their transparency.

During the period of treatment, care must be taken when driving a car and working with mechanisms (after the application of eye drops, the pupil may expand and become blurred).

Instructions

Tetrisolin (Tetryzolinum)