Adzhikold Hotmix - instructions for use, dose, side effects, contraindications

Citric acid anhydrous 443.5 mg, tartaric acid 50.00 mg, sodium saccharinate 50 mg, sodium citrate dihydrate 500 mg, sucrose 2988.5 mg, orange flavor 125 mg, dye quinoline yellow 3 mg, silicon dioxide colloidal anhydrous 20 mg.

Description:Non-uniform crystalline powder of light orange color with a characteristic orange odor and with the possible presence of colorless crystals.

Pharmacotherapeutic group:Remedy for elimination of symptoms of acute respiratory disease and "colds" (analgesic non-narcotic remedy + alpha-adrenomimetic + vitamin)

ATX: & nbsp

N.02.B.E Anilides

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:Combined drug. Paracetamol has antipyretic and analgesic effect: reduces pain syndrome, which is observed in catarrhal conditions - sore throat, headache, muscle and joint pain, reduces heat. Phenylephrine has vasoconstrictive effect - reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and accessory sinuses. Ascorbic acid (vitamin C) replenishes the increased need, in vitamin FROM for colds and flu, especially at the initial stages of the disease. Increases the body's resistance to infectious diseases.

Indications:

Symptomatic treatment of "colds", flu, ARVI (febrile syndrome, pain syndrome, rhinorrhea).

Contraindications:

Hypersensitivity to paracetamol and other components that make up the drug; taking other preparations containing substances that are part of Adjikold® Hotmix; simultaneous reception of tricyclic antidepressants, MAO inhibitors (including within 14 days after their cancellation), beta-blockers; pregnancy, lactation; children's age (up to 12 years). Diabetes mellitus, arterial hypertension, prostatic hyperplasia, angle-closure glaucoma.

Carefully:

The pronounced atherosclerosis of the coronary arteries, thyrotoxicosis, pheochromocytoma, bronchial asthma, chronic obstructive pulmonary disease,deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), hepatic and / or renal insufficiency, sucrose / isomaltose deficiency, fructose intolerance, glucose-galactose malbobsorption (since the drug contains sucrose) severe aortic stenosis, acute myocardial infarction, tachycardia, marked renal / hepatic insufficiency.

Dosing and Administration:The contents of 1 sachet pour into a glass, pour hot water, mix until completely dissolved - and drink. Take the drug with a lot of liquid 1-2 hours after eating. Adults and children over 12 years: take one by one, a bag 3-4 times a day with intervals between doses 4-6 hours. The maximum daily dose is 4 sachets. The course of treatment is not more than 5 days.

Side effects:

Allergic reactions (including skin rash, itching, hives, angioedema), dizziness, falling asleep, increased excitability, mydriasis; increased blood pressure, tachycardia; nausea, vomiting, epigastric pain; dry mouth; urine retention, accommodation paresis,increased intraocular pressure; anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, hepatotoxicity, nephrotoxicity (papillary necrosis); bronchial obstruction.

Overdose:

Symptoms: pallor of the skin, anorexia, nausea, vomiting, hepatonecrosis; an increase in the activity of "hepatic" transaminases, an increase in prothrombin time. When overdosing, it is urgent to see a doctor.

Treatment: gastric lavage followed by administration of activated charcoal; symptomatic therapy, the introduction of methionine after 8-9 hours after an overdose and N-acetylcysteine - after 12 h.

Interaction:

Strengthens the effects of MAO inhibitors, sedatives; ethanol. Antidepressants, antiparkinsonics, antipsychotics, phenothiazine derivatives - increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs. Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine,simultaneous administration of halothane increases the risk of ventricular arrhythmia. Guanethidine enhances the alpha-adrenostimulating effect of phenylephrine. Ascorbic acid It increases the risk of crystalluria salicylates in the treatment of sulfonamides short-acting, slow excretion by the kidneys acids, increases the excretion of drugs having an alkaline reaction (including alkaloids), reduces blood levels of oral contraceptives.

While appointing Adzhikolda® Hotmiks with barbiturates, phenytoin, carbamazepine, rifampicin and other inducers of microsomal liver enzymes increased risk of hepatotoxic action of paracetamol.

Special instructions:

During treatment should refrain from taking alcohol, sleeping pills and anxiolytic (tranquilizers) medicines. Do not take with other medicines containing paracetamol. If symptoms of the disease do not pass within 3-5 days, consult a doctor.

Distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.

Effect on the ability to drive transp. cf. and fur:At the indicated doses the preparation does not affect the ability to govern vehicles and service mechanisms.

Form release / dosage:

Powder for solution for oral administration (orange).

Packaging:For 5 g of the drug in a single-dose package of aluminum foil, laminated polyethylene. 5 or 10 single-dose packages in a cardboard pack together with instructions for use.

Storage conditions:

In a dry, protected from light place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LS-001660

Date of registration:19.10.2012

Expiration Date:Unlimited

The owner of the registration certificate:Agio Pharmaceuticals Ltd.Agio Pharmaceuticals Ltd. India

Manufacturer: & nbsp

AGIO PHARMACEUTICALS, Ltd. India

Representation: & nbspAgio Pharmaceuticals Ltd.Agio Pharmaceuticals Ltd.

Information update date: & nbsp04.02.2017

Illustrated instructions

Instructions

Adjikold® Hotmix (Agicold® Hotmix)