PREPARATION SHOULD BE ACCEPTED ONLY IN RECOMMENDED DOSES.
If you suspect an overdose, even if you feel well, you should stop using the drug and immediately seek medical help.
Symptoms (due to paracetamol): within 24 hours: pallor of the skin, decreased appetite, nausea, vomiting, abdominal pain. After 12-48 hours, signs of impaired liver function may appear. There may be signs of impaired glucose metabolism and metabolic acidosis. In case of severe poisoning, severe hepatic insufficiency may develop, including hepatic encephalopathy, coma, and death. Acute renal failure with acute tubular necrosis, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, can develop without a serious impairment of liver function.
There are reports of cardiac arrhythmias and pancreatitis in case of an overdose of paracetamol.In the early period, the symptomatology can be limited only by nausea and vomiting and may not reflect the severity of the overdose or the risk of injury to the internal organs.
Treatment: within the first hour after the proposed overdose, it is advisable to assign activated carbon inside. Four or more hours after the alleged overdose, a determination of the paracetamol concentration in the plasma is required (an earlier determination of the paracetamol concentration may be unreliable). Treatment with acetylcysteine can be carried out up to 24 hours after taking paracetamol, but the maximum hepatoprotective effect can be obtained in the first 8 hours after an overdose. After that, the effectiveness of the antidote drops sharply. In case of necessity acetylcysteine can be administered intravenously. In the absence of vomiting an alternative option (in the absence of the possibility of rapid receipt of inpatient care) is the appointment of methionine inside. Treatment of patients with severe impairment of liver function 24 hours after taking paracetamol should be done in conjunction with specialists from the toxicology center or specialized department of liver diseases.
Symptoms (due to phenylephin): irritability, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, increased excitability, reflex bradycardia. In severe cases of overdose, it is possible to develop hallucinations, confusion, convulsions, arrhythmias.
Treatment: symptomatic therapy, with severe hypertension, the use of alpha-adrenoblockers, such as phentolamine.
Symptoms (due to ascorbic acid): high doses of ascorbic acid (more than 3000 mg) can cause temporary osmotic diarrhea and impairment of the gastrointestinal tract, such as nausea, discomfort in the stomach. Manifestations of an overdose can be categorized as those caused by severe liver damage, as a result of an overdose of paracetamol.
Treatment: symptomatic, forced diuresis.