Gripend HotActiv Max - instructions for use, dose, side effects, contraindications

Excipients: sucrose, sodium citrate, citric acid, acesulfame potassium, aspartame, quinoline yellow colorant, lemon flavorant F / 29088, lemon flavor F / 29089, lemon flavor F / 28151, lemon flavorant 50G476 / AG10504

Description:White powder with a yellowish hue of color with a characteristic smell of lemon

Pharmacotherapeutic group:ARI and "colds" of symptoms remedy (analgesic non-narcotic agent + alpha-adrenomimetic + vitamin)

ATX: & nbsp

N.02.B.E Anilides

N.02.B.E.51 Paracetamol in combination with other drugs, excluding psycholeptics

Pharmacodynamics:

Gripend® HotActiv Max with lemon flavor is a combined drug, the effect of which is due to its constituent components, has antipyretic, analgesic, vasoconstrictive effect, eliminates the symptoms of "colds". Paracetamol has analgesic and antipyretic effect. Due to the inhibition of cyclooxygenase, arachidonic acid prevents the formation of prostaglandins in the central nervous system (CNS).

Fsnylephrine reduces the swelling of the mucous membranes of the sinuses of the nose, thereby facilitating breathing. Ascorbic acid replenishes the increased need for vitamin C for colds and flu.

Indications:

Gripend® HotActive Max is used to eliminate the symptoms of colds and flu such as fever, headache, chills, joint and muscle pain, nasal congestion, pain in the sinuses of the nose and in the throat.

Contraindications:

Hypersensitivity; marked renal or hepatic insufficiency; hyperthyroidism; diseases of the cardiovascular system (pronounced aortic stenosis, acute myocardial infarction, tachyarrhythmia); arterial hypertension; hyperplasia of the prostate; angle-closure glaucoma; simultaneous reception of tricyclic antidepressants, beta-adrenoblockers, monoamine oxidase inhibitors (MAO) (including within 14 days after their cancellation),other paracetamol-containing drugs; Diabetes mellitus and hereditary impairment of glucose absorption; children's age (up to 18 children); diseases of the blood system.

Carefully:With caution in benign hyperbilirubinemia, deficiency of glucose-6-phosphate dehydrogenase.

Pregnancy and lactation:

The drug can be used during pregnancy if the potential benefit to the mother exceeds the possible risk to the fetus. It should not be used during lactation.

Dosing and Administration:

Inside, 1 packet every 4-6 hours (no more than 4 bags per day). The contents of the sachet are dissolved in 250 ml of hot water until complete dissolution.

The drug is not recommended for more than five days without consulting a doctor. If symptoms persist, consult a physician.

Do not exceed the indicated dose. In case of an overdose, seek medical help immediately.

Side effects:

In recommended doses, the drug is usually well tolerated.

Paracetamol rarely has a side effect. Sometimes allergic reactions are possible, for example, skin rash, hives, angioedema. Rarely - thrombocytopenia, leukopenia, agranulocytosis. When.long-term use with excess of the recommended dose can be observed hepatotoxic and nephrotoxic effect.

Phenylephrine can cause nausea, headache, a slight increase in blood pressure and in rare cases, heartbeat, which pass after the drug is discontinued.

In case of any undesired reactions, consult a physician.

Overdose:

Symptoms: nausea, vomiting, anorexia, stomach pain, sweating, pale skin, cardiac arrhythmias, increased activity of "liver" transaminases, increased prothrombin time, hepatonecrosis and coma!

Treatment: gastric lavage during the first 4 hours of poisoning, taking activated carbon; symptomatic therapy. Specific antidote - acetylcysteine.

In case of an overdose, immediately consult a doctor.

Interaction:

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, fennylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which makes it possible to develop severe intoxication with small overdoses. Paracetamol enhances the effects of MAO inhibitors, sedatives, ethanol. With simultaneous admission with antidepressants, antiparkinsonian antipsychotic drugs, phenothiazine derivatives - the risk of urine retention, dry mouth, constipation increases.

Phenylephrine reduces the hypotensive effect of guanethidine.

Guanethidine increases alpha-adrenostimulating effect, and tricyclic antidepressants - sympathomimetic effects of phenylephrine.

Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of diuretic drugs.

Metoclopramide, domperidone increase the rate of absorption of paracetamol, and colestramine reduces.

Vitamin C increases the absorption of penicillin, iron, reduces the effect of heparin and indirect anticoagulants, increases the risk of cristallouria in the treatment of salicylates. Absorption of vitamin C decreases with simultaneous use with oral contraceptives.

Vitamin C slows the excretion of kidney acids, reduces the reabsorption of drugs that have an alkaline reaction (including alkaloids).

Vitamin C in combination with deferoxamine increases the toxic effect of iron on tissues (especially on the heart, causing the development of heart failure), the administration of preparations containing ascorbic kshhotu is carried out after determining the concentration deferoxamine and the determination of iron excretion, not earlier than 1-2 hours after the infusion of deferoxamine.

Special instructions:

Distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.

Do not use simultaneously with other medicines containing paracetamol, as well as non-narcotic analgesics, non-steroidal

anti-inflammatory drugs (metamizole, acetylsalicylic acid, ibuprofen etc.), barbiturates, antiepileptic drugs, rifampicin,

chloramphenicol.

One sachet contains 1.936 g of sucrose, which corresponds to 0.2 bread units.

Form release / dosage:

Powder for solution for oral administration.

Packaging:

5 grams of powder in a sachet of boom / polyethylene / Al / polyethylene.

For 5 or 8 sachets in a cardboard box with instructions for use.

Storage conditions:

At a temperature not higher than 25 ° C, out of the reach of children.

Shelf life:

2 years

Do not use the drug after the expiration date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-006670/09

Date of registration:20.08.2009

The owner of the registration certificate: YuS Pharmacy LLC YuS Pharmacy LLC Poland

Manufacturer: & nbsp

WRAFTON Laboratories, Limited United Kingdom

Information update date: & nbsp27.09.2015

Illustrated instructions

Instructions

Gripend® HotActive Max (Gripend® HotActive Max)