Clinical and pharmacological group: & nbsp
Antacids
Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):ONLS
VED
АТХ:A.02.A.F Antacids in combination with drugs that reduce gassing in the intestine
Pharmacodynamics:Neutralization of hydrochloric acid in the stomach, thereby increasing pH in the gastrointestinal tract. It does not affect the production of hydrochloric acid. Included in the simethicone (a mixture of liquid dimethicones containing highly purified silica) is a surfactant, reduces the surface tension of gas bubbles in the digestive tract, leading to their rupture; The gases released by the decay of the bubbles are absorbed by the walls of the intestine or are excreted by peristalsis, As a result, gas formation in the digestive tract decreases.
Pharmacokinetics:Absorption is low, excreted through the gastrointestinal tract.
Indications:Conditions accompanied by high acidity, as well as in violation of the integrity of the gastrointestinal mucosa and as part of complex therapy.
Intensified gas formation in the gastrointestinal tract (Remkheld's syndrome, the formation of gases in the postoperative period, flatulence, aerophagia).
XI.K20-K31.K20 Esophagitis
XI.K20-K31.K21.0 Gastroesophageal reflux with esophagitis
XI.K20-K31.K25 Stomach ulcer
XI.K20-K31.K26 Duodenal ulcer
XI.K20-K31.K27 Peptic ulcer of unspecified site
XI.K20-K31.K29 Gastritis and duodenitis
XI.K20-K31.K30 Dyspepsia
XI.K80-K87.K85 Acute pancreatitis
XI.K80-K87.K86.1 Other chronic pancreatitis
XVIII.R10-R19.R12 Heartburn
XVIII.R10-R19.R14 Meteorism and related conditions
XIX.T51-T65.T55 Toxic effect of soaps and detergents
Contraindications:Pregnancy; hypersensitivity to the components of the drug; hypophosphatemia; chronic kidney disease; Alzheimer's disease.
Carefully:Appendicitis, bleeding in the gastrointestinal tract, ulcerative colitis, diverticulitis, colostomy, chronic diarrhea, ileostomy, children under 12 years.
Pregnancy and lactation:This drug is not classified FDA. The use of antacids is considered safe, except for long-term administration in large doses. Adequate and well-controlled studies in humans have not been conducted, but there have been reports of such side effects of antacids as hypercalcemia, hypomagnesemia, hypermagnesia, and an increase in tendon reflexes in the fetus and / or newborns whose mothers have taken aluminum, calcium or magnesium-containing antacids , especially in high doses.Animal studies were not conducted.
Dosing and Administration:With diseases of the intestines - before meals, with stomach diseases - after eating.
Take 5-10 ml (minimum dose) for 30 minutes before meals or 1-2 hours after meals 5-6 times a day and at night.
If you need to stop the pain syndrome, you can take additional doses.
The drug is continued for 4-6 weeks, until the symptoms disappear.
Children under 12 years with caution, 2-5 years - 5 ml three times a day, 5-12 years - 5-10 ml 3-4 times a day, 12-18 years - 5-10 ml 4 times a day after food and overnight if necessary.
Before use, the suspension must be shaken well.
Side effects:On the part of organs GIT: in rare cases, a violation of taste, nausea, vomiting, diarrhea, constipation.
From the side of metabolism: with prolonged intake of large doses, hypophosphatemia, hypercalcaria, nephrocalcinosis, hypermagnesia, hyperaluminia may develop.
Other: allergic reactions, exacerbation of osteoarthritis and Alzheimer's disease (in elderly patients), osteomalacia, osteoporosis, encephalopathy. In patients with chronic kidney disease, there may be a decrease in blood pressure, hyporeflexia and thirst.
Overdose:Symptoms. Long-term use of high doses can lead to the development of hypermagnesemia, hypocalcemia, which is characterized by rapid fatigue, facial flushing, exhaustion, muscle weakness, bone pain and inadequate behavior. There may also be signs of metabolic alkalosis: mood changes, mental disorders, numbness or pain in the muscles, nervousness and fatigue, slowing of breathing, unpleasant taste sensations. Treatment symptomatic: it is necessary to take measures to quickly remove the drug - gastric lavage, stimulation of vomiting, reception of activated charcoal.
Interaction:The drug slows the absorption of other drugs and can reduce their effectiveness through the formation of complexes, so the interval between drug intake should be at least 2 hours. Reduces the effectiveness of tetracyclines, H2antigistamines, digoxin, ciprofloxacin, salicylates, aminazine, isoniazid, beta-adrenoblockers, indomethacin, ketoconazole, and others.
It is not recommended simultaneous reception with drugs that oxidize urine (ascorbic acid, ammonium chloride, potassium and sodium phosphate, etc.).
Vitamins of the group D - hypermagnesia is possible.
Special instructions:With prolonged use, sufficient intake of phosphate with food is necessary.
Simethicone is not recommended for use in colic in newborns.
With prolonged admission, it is necessary to monitor the calcium, aluminum, magnesium and phosphate levels in the blood.