Absorption after oral administration - fast, high, bioavailability - 40%; TCam for oral administration of 500 mg - 2 h, Cmah - 3-4 ng / ml. Connection with plasma proteins - 20%.
Evenly distributed in the organs and tissues of the body,is found in therapeutic concentrations in pleural, peritoneal, amniotic and synovial fluids, cerebrospinal fluid, contents of blisters, urine (high concentrations), intestinal mucosa, bones, gall bladder, lungs, female genital tract, bile, bronchial secretion (in purulent bronchial secret accumulation is weak), paranasal sinuses, middle ear fluid, saliva, fetal tissues. Poor penetration through the BBB (permeability increases with inflammation).
It is excreted mainly by the kidneys (70-80%), and in the urine very high concentrations of the unchanged antibiotic are created; partially with bile, in nursing mothers - with milk. Do not cumulate. Removed during hemodialysis.