Intravenously (intravenously) (jet, drip), intramuscularly (in / m). Doses and dosing regimen are chosen individually depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen. In cases of moderate infections, adults intramuscularly - 250-500 mg every 6-8 hours. In case of severe infection, 1-2 g 3-4 times a day or intravenously at 500 mg every 6 hours.
Listeriosis - 50 mg / kg every 6 hours intramuscularly or intravenously.
With meningitis - 14 g / day; the frequency of administration is 6-8 times.
Adults with gonococcal urethritis - intramuscularly 0.5 g 2 times for one day; with gonorrheal uncomplicated urethritis - once 0.5 g.
For the prevention of bacterial endocarditis in high-risk patients undergoing dental, endoscopic interventions, "small" surgeries on ENT organs, as well as operations on the organs of the gastrointestinal tract or bile ducts - 2 g IV or IM for 30 min before the procedure or operation; if necessary, after 6 hours, re-injected at a dose of 1 g.
Children with severe and medium-heavy infections - intramuscularly 25-50 mg / kg 4 times a day; when meningitis daily dose is 100-200 mg / kg for 6-8 injections.
Children over 4 years of age are prescribed 1-2 g / day; up to 1 year - at the rate of 100 mg / kg; 1-4 years - 100-150 mg / kg. The daily dose is divided into 4-6 receptions.
Newborns weighing up to 2 kg - 25-50 mg / kg every 12 hours in the first week of life, then 50 mg / kg every 8 hours; newborns with a body weight of 2 kg and above - 50 mg / kg every 8 hours in the first week of life, then 50 mg / kg every 6 hours.
Children for the prevention of bacterial endocarditis - 50 mg / kg for 30 minutes before the procedure; if necessary,after 6 hours, re-injected at a dose of 25 mg / kg. The duration of treatment depends on the severity of the disease (7-14 days or more).
Preparation of solutions and administration. Solutions are prepared ex tempore.
For the / m introduction, 2 ml of water for injections is added to the contents of the vial (500 mg). For IV injection - to the contents of the bottle (500 mg), add 5 ml of water for injection, injected iv slowly for 3-5 minutes.
With a single dose exceeding 2 g, the drug is administered intravenously drip. To do this, 5 ml of water for injection are added to the contents of the vial (500 mg), the resulting solution is added to 125-250 ml of a 0.9% solution of sodium chloride or 5% solution of dextrose, injected at a rate of 60-80 drops per minute.
Solutions used immediately after preparation, it is unacceptable to add other medicines to them.