Intramuscularly, intravenously.
Doses and dosing regimen are chosen individually depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen. The average therapeutic dose for adults and children with a body weight of more than 40 kg - 250-500 mg, which is injected in / m or IV (jet, drip) every 6 hours. In case of severe infection, the daily dose can be increased to 10 g. For the treatment of gonorrhea, 2 doses of 500 mg with an interval of 8 or 12 hours. For the treatment of bacterial meningitis and sepsis, the daily dose of the drug is 150,200 mg / kg, divided by 6-8 IV infusions with an interval of 3-4 hours. The maximum daily dose is 8-14 g.
For the prevention of bacterial endocarditis in patients from the high-risk group who undergo dental, endoscopic interventions, "small" surgeries on ENT organs, as well as operations on the organs of the gastrointestinal tract or bile ducts - 2 g IV or IM 30 minutes before the procedure or operation; if necessary, after 6 hours, re-injected at a dose of 1 g.
In children weighing less than 40 kg for the treatment of infections of the respiratory tract, skin and soft tissues, the daily dose of ampicillin is 25-50 mg / kg; To treat infections of the abdominal cavity or urinary tract, 50-100 mg / kg per day is administered. The daily dose is divided into 4 injections at an interval of 6 hours. For the treatment of septicemia or infections of the central nervous system (bacterial meningitis), the daily dose of 100-200 mg / kg is divided into 6-8 intravenously injected with an interval between administrations of 3-4 h.
For the prevention of bacterial endocarditis - 50 mg / kg IV or IM for 30 minutes before the procedure or operation; if necessary, after 6 hours, re-injected at a dose of 25 mg / kg.
Newborns under the age of 7 days with a body weight of less than 2 kg administered intravenously or intravenously at 25-50 mg / kg every 12 hours, with a body weight of more than 2 kg - 25-50 mg / kg every 8 hours.
Newborns aged 7 up to 28 days with a body weight of 1.2-2 kg administered at 25-50 mg / kg every 8 hours, with a body weight of more than 2 kg - 25-50 mg / kg every 6 hours.
For the treatment of bacterial meningitis: in newborns under 7 days of daily dose of ampicillin - 200-300 mg / kg, which is divided into 3 in / in the introduction at an interval of 8 hours; in newborns aged 7 to 28 days the daily dose is 300 mg / kg, which is divided into 4-6 intravenous injections with an interval of 4-6 hours.
The duration of the / m introduction is 7-14 days. The duration of IV application is 5-7 days, with the subsequent transition (if necessary) to the / m introduction. It is recommended to continue the introduction of ampicillin for another 48-72 hours after the disappearance of clinical signs of the disease.
Rules for solution preparation and introduction
For Preparing the solution for the / m administration as a solvent, sterile water for injection is used. In a vial containing 500 mg - 1.8 ml, 1 g - 3.5 ml and 2 g - 6.8 ml of solvent.
For intravenous string introduction: 5 ml of water for injections are added to a vial containing 500 mg of ampicillin; injected iv slowly for 3-5 min; 7.4 ml are added to bottles containing 1 g of the preparation, and 2 grams to 14.8 ml of water for injection; injected iv slowly for 10-15 min.
With a single dose exceeding 2 g, the drug is administered intravenously drip. To do this, the drug (2-4 g) is dissolved in 7.5-15 ml of water for injection, then the resulting solution is added to 125-250 ml of a 0.9% solution of sodium chloride or 5% solution of dextrose and injected at a rate of 60-80 drops per minute .