Intramuscularly, intravenously (struino or drip). Doses and dosing regimen are chosen individually depending on the severity of the course, the localization of the infection and the sensitivity of the pathogen. The average therapeutic dose for adults and children weighing more than 40 kg is 0.25-0.5 g, which is injected in / m or IV every 6 hours.
In case of severe infection, the daily dose may be increased to 10 g.
For the treatment of gonorrhea, 2 doses of 0.5 g are administered at intervals of 8 or 12 hours.
For the treatment of bacterial meningitis and sepsis, the daily dose of the drug is 150 to 200 mg / kg, divided by 6-8 intravenously administrations with an interval of 3-4 hours. The maximum daily dose is 8-14 g.
For the prevention of bacterial endocarditis in patients of high-risk group undergoing dental, endoscopic interventions, "small" surgeries on ENT organs, as well as operations on the organs of the gastrointestinal tract or bile ducts - 2 g IV or IM for 30 min before the procedure or operation; if necessary, after 6 hours, re-injected at a dose of 1 g.
In children with a body weight of less than 40 kg, the daily dose of ampicillin for the treatment of respiratory, skin and soft tissue infections is 25-50 mg / kg; To treat infections of the abdominal cavity or urinary tract, 50-100 mg / kg per day is administered. The daily dose is divided into 4 injections with an interval of 6 hours.
To treat septicemia or infections of the central nervous system (bacterial meningitis), the daily dose, equal to 100-200 mg / kg, is divided into 6-8 intravenous administrations with an interval between administrations of 3-4 hours.
For the prevention of bacterial endocarditis - 50 mg / kg IV or IM for 30 minutes before the procedure or operation; if necessary, after 6 hours, re-injected at a dose of 25 mg / kg.
The duration of the / m introduction is 7-14 days. The duration of IV application is 5-7 days, with the subsequent transition (if necessary) to the / m introduction. It is recommended to continue the introduction of ampicillin another 48-72 h after disappearance of clinical signs of the disease.
Solution for intramuscular injection is prepared extepore, adding to the contents of the vial (0.25 g, 0.5 g and 1 g) 2 ml of water for injection.
For intravenous administration, a single dose of the drug (not more than 2 g) is dissolved in 5-10 ml of water for injection or isotonic sodium chloride solution and injected slowly for 3-5 minutes (1-2 g for 10-15 minutes).With a single dose exceeding 2 g the drug is administered intravenously drip. For intravenous drip, a single dose of the drug (2-4 g) is dissolved in a small amount of water for injection, 7.5-15 ml, respectively, then the resulting antibiotic solution is added to 125-250 ml of isotonic sodium chloride solution or 5-10% solution of dextrose and injected at a rate of 60-80 drops per minute. With the drop introduction to children, a 5-10% dextrose solution (30-50 ml, depending on the age) is used as a solvent. Solutions used immediately after preparation, it is unacceptable to add other medicines to them.