The frequency of adverse reactions listed below was determined according to the following criteria: very often (not less than 1/10), often (more than 1/100, less than 1/10); sometimes (more than 1/1000, less than 1/100); rarely (more than 1/10000, less than 1/1000); very rarely (less than 1/10000), including individual messages.
From the cardiovascular system: very often - the "tides" of blood to the face.
From the musculoskeletal system: very often - arthralgia, bone pain, stiffness of joints, arthritis; rarely a trigger finger.
On the part of the reproductive system: often vaginal dryness, vaginal bleeding (mainly during the first weeks after cancellation or replacement of previous hormonal therapy on anastrozole).
From the skin and skin appendages: very often - skin rash; often thinning hair, alopecia; infrequently - hives, vasculitis, purpura (Shenllein-Genocha), erythema multiforme; very rarely - polymorphic erythema (Stevens-Johnson syndrome).
On the part of the digestive system: very often - nausea; often diarrhea, vomiting, anorexia.
From the hepatobiliary system: often - increased activity alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase; rarely - increased activity of gamma-glutamyl transferase and bilirubin concentration, hepatitis.
From the nervous system: very often - headache; often - increased drowsiness, carpal tunnel syndrome (mainly observed in patients with risk factors for this disease).
From the side of metabolism: often - hypercholesterolemia. Admission of the drug can cause a decrease in bone mineral density "due to a decrease in the concentration of circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures
Allergic reactions: often - allergic reactions; very rarely - anaphylactoid reactions, angioedema, hives, anaphylactic shock.
Other: very often - asthenia.