The frequency of adverse reactions listed below was determined according to the following criteria: very often (not less than 1/10), often (more than 1/100 less than 1/10): sometimes (more than 1/1000, less than 1/100); rarely (more than 1/10000, less than 1/1000): very rarely (less than 1/10000), including individual messages.
From the side of the vessels: Often - "tides" of blood to the face.
From the side of the musculoskeletal and connective tissue: very often - arthralgia / joint stiffness, arthritis; often - pain in the bones, myalgia; infrequently - a trigger finger.
From the genitals and the breast: often - dry mucous sheaths of the vagina, vaginal bleeding (mainly during the first weeks after cancellation or replacement of previous hormonal therapy on anastrozole).
From the skin and subcutaneous tissues: very often - skin rash: often - thinning hair, alopecia, allergic reactions; infrequently - urticaria: rarely - erythema multiforme, anaphylactoid reaction, skin vasculitis (including isolated cases of purpura (Shenlaine-Henoch syndrome)), very rarely - Stevens-Johnson syndrome, angioedema.
From the gastrointestinal tract: very often - nausea; often - diarrhea, vomiting.
From the liver and bile ducts: often - increased activity of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase; infrequently - increased activity of gamma-glutamyltransferase and bilirubin concentration, hepatitis.
From the nervous system: very often - headache; often - drowsiness, carpal tunnel syndrome (mainly observed in patients with risk factors of the disease), impaired sensitivity (including paresthesia, loss or perversion of taste sensations).
From the side of metabolism and nutrition: often - anorexia, hypercholesterolemia: infrequently - hypercalcemia (with / without increasing the concentration of parathyroid hormone). Admission of the drug may cause a decrease in bone mineral density due to a decrease in the concentration of circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures.
General disorders: very often - asthenia of mild or moderate severity.
Adverse events noted in clinical trials that are not associated with anastrozole use: anemia, constipation, dyspepsia, back pain, abdominal pain, increased blood pressure, weight gain, depression, insomnia, dizziness, anxiety, paresthesia.