Side effects recorded more often than single observations are listed below for organs and systems, indicating the frequency of their occurrence. Determination of the frequency of adverse reactions: very often (> 10%); often (1-10%); infrequently (0.1-1%); rarely (0,01 - 0,1%); very rarely (<0.01%).
From the cardiovascular system: very often - "hot flashes" of heat, increased blood pressure; often - vasodilation, ischemic cardiovascular diseases.
From the musculoskeletal system: very often - arthralgia, joint stiffness, arthritis, back pain, decreased bone mineral density, osteoporosis and bone fractures; often - pain in the bones, myalgia; infrequently - "trigger finger" or "snapping finger" (impaired ability to straighten a finger, usually middle or anonymous).
From the reproductive and genitourinary system: often - dryness of the vaginal mucosa, vaginal bleeding (mainly during the first weeks after the abolition or replacement of previous hormonal therapy for anastrozole preparations), vulvovaginitis, vaginitis, pelvic pain; infrequently - mucous discharge from the vagina, urinary tract infection, chest pain; rarely - endometrial cancer, neoplasms in the chest.
From the side of the blood and lymphatic system: very often - lymphedema; infrequently, anemia.
From the digestive system: very often - nausea, vomiting; often - diarrhea, constipation, dyspepsia, increased activity of alkaline phosphatase, alanylaminotransferase, aspartate aminotransferase; infrequently - abdominal pain, increased activity of gamma-glutamintransferase and bilirubin concentration, hepatitis, dry mouth.
From the nervous system: very often - headache, dizziness, sleep disturbances, depression; often - carpal tunnel syndrome (mainly observed in patients with risk factors for this disease), a sense of anxiety, paresthesia.
From the sense organs: infrequently, cataract.
From the respiratory system: very often - pharyngitis, coughing, shortness of breath; infrequently - pain in the chest, sinusitis, bronchitis.
From the side of metabolism: very often peripheral edema; often - anorexia, hypercholesterolemia, hypercalcemia (with or without increased parathyroid hormone concentration), weight gain.
From the skin and appendages: very often - skin rash; often thinning hair, alopecia; infrequently, erythema multiforme (Stevens-Johnson syndrome), cutaneous vasculitis (including isolated cases of purpura (Shenlaine-Genoch syndrome)). Allergic reactions: often - allergic reactions; infrequently - hives; rarely anaphylactoid reaction; very rarely - angioedema.
Other: very often - asthenia.
If you notice any other side effects not listed in the instructions, inform the doctor about it.