Determination of the frequency of adverse reactions: very often (not less than 1/10); often (more than 1/100, less than 1/10); sometimes (more than 1/1000, less than 1/100); rarely (more than 1/10000, less than 1/1000); very rarely (less than 1/10000), including individual messages.
From the side of the vessels: very often - "hot flashes".
From the musculoskeletal and connective tissue: very often - arthralgia / joint stiffness, arthritis, often - bone pain, myalgia, infrequently - trigger finger.
From the genitals and the breast: often - dryness of the mucous membrane of the vagina; vaginal bleeding (mainly during the first weeks after the cancellation or change of previous hormone therapy on anastrozole).
From the skin and subcutaneous tissues: very often skin rash, often thinning of hair (alopecia), allergic reactions, infrequent urticaria, rarely erythema multiforme, anaphylactoid reaction, skin vasculitis (including isolated cases of purpura (Shenlaine-Henoch syndrome)) , very rarely - Stevens-Johnson syndrome, angioedema.
From the gastrointestinal tract: very often - nausea, often - diarrhea, vomiting.
From the liver and bile ducts: often - increased activity of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, infrequently - increased activity of gamma-glutamyl transferase and bilirubin concentration, hepatitis.
From the nervous system: very often - headache, often - drowsiness,Carpal tunnel syndrome (mainly observed in patients with risk factors of the disease), sensitivity disorders (including paresthesia, loss or perversion of taste sensations).
From the side of metabolism and nutrition: often - anorexia, hypercholesterolemia, infrequently - hypercalcemia (with / without increased concentration parathyroid hormone). Admission of the drug may cause a decrease in bone mineral density due to a decrease in the concentration of circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures.
General disorders: very often - asthenia of mild or moderate severity.
Adverse events observed during clinical trials that are not associated with taking anastrozole: anemia, constipation, dyspepsia, back pain, abdominal pain, increased blood pressure, weight gain, depression, insomnia, dizziness, anxiety, paresthesia.