The frequency of adverse reactions listed below was determined according to the following criteria: very often (not less than 1/10), often (more than 1/100, less than 1/10), infrequently (more than 1/1000, less than 1/100), rarely more than 1/10000, less than 1/1000). very rarely (less than 1/10000), including individual messages.
From the side of the vessels: very often - the "tides" of blood to the face.
From the musculoskeletal and connective tissue: very often - arthralgia / joint stiffness, arthritis; often - pain in the bones, myalgia; infrequently - a trigger finger.
From the genitals and breast: often - dryness of the mucous membrane of the vagina, vaginal bleeding (mainly during the first weeks after cancellation or change of previous hormone therapy on anastrozole).
From the skin and subcutaneous tissues: very often - skin rash; often, hair loss, alopecia, allergic reactions; infrequently, urticaria; rarely - erythema multiforme, anaphylactoid reaction, skin vasculitis (including isolated cases of purpura (Shenlaine-Henoch syndrome)), very rarely - Stevens-Johnson syndrome, angioedema.
From the gastrointestinal tract: very often - nausea; often diarrhea, vomiting.
On the part of the liver and bile ducts: often - increased activity of alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase and, rarely - increased activity of gamma-glutamintransferase; infrequently - excess of activity of gamma-glutamyltransferase and bilirubin concentration, hepatitis.
From the nervous system: very often - headache; often - drowsiness, carpal tunnel syndrome (mainly observed in patients with risk factors of the disease), sensitivity disorders (including paresthesia, loss or perversion of taste sensations).
From the side of metabolism and nutrition: often - anorexia, hypercholesterolemia; infrequently - hypercalcemia (with / without increasing the concentration of parathyroid hormone). Reception of the drug can cause a decrease in bone mineral density due to a decrease in the concentration of circulating estradiol, thereby increasing the risk of osteoporosis and bone fractures.
Common disorders: very often - plants of mild or moderate severity.
Adverse events noted in clinical trials that are not associated with anastrozole use: anemia, constipation, dyspepsia, back pain, abdominal pain, increased blood pressure, weight gain, depression, insomnia, dizziness, anxiety, paresthesia.