Included in the formulation
АТХ:A.05.B.A Preparations for the treatment of liver diseases
Pharmacodynamics:The connection of glutamic acid with arginine, which contributes to detoxification ammonia and removing it from the body by activating the synthesis of urea in the ornithine cycle. Including the drug increases the excretion of the central nervous system of ammonia, reducing its neurotoxic effect.
Has antioxidant, membrane-stabilizing activity. When alcohol intoxication accelerates the utilization of ethanol, stimulating the work of alcohol dehydrogenase, also contributes to the removal of products of the decomposition of ethanol due to the enhanced formation of succinic acid.
Pharmacokinetics:Not studied.
Indications:It is used for acute and chronic hepatitis of any etiology, poisoning with hepatotropic poisons (pale toadstool,medicines), cirrhosis of the liver, acute alcohol intoxication, abstinence.
I.B15-B19.B17.1 Acute hepatitis C
I.B15-B19.B16 Acute hepatitis B
I.B15-B19.B15 Acute hepatitis A
I.B15-B19.B18.2 Chronic viral hepatitis C
I.B15-B19.B18.1 Chronic viral hepatitis B without delta-agent
XI.K70-K77.K70 Alcoholic liver disease
XI.K70-K77.K71 Toxic liver disease
XI.K70-K77.K74 Fibrosis and cirrhosis of the liver
XIX.T51-T65.T51 Toxic effect of alcohol
Contraindications:Feverish condition, acute psychosis, increased excitability of the central nervous system, severe renal failure.
Individual intolerance.
Carefully:It is used with caution in people with a history of allergic history.
Pregnancy and lactation:Recommendations for Food and Drug Administration (US Food and Drug Administration) - not defined. Information about ingestion in breast milk is not available. When treating the drug, it is necessary to stop breastfeeding. It is not recommended to use the drug during pregnancy.
Dosing and Administration:Ingestion of 3 tablets (0.75 g) 3 times a day, regardless of food intake for 15 days. If necessary, the course of treatment is extended to 20 days.
Parenterally, intravenously drip on isotonic sodium chloride solution - 2 times a day at a rate of 60 drops per minute. Not more than 8 grams per day.
The highest daily dose: 2 g.
The highest single dose: 8 g.
Side effects:Nausea immediately after ingestion disappears on its own.
Allergic reactions.
Overdose:Pectoral pain, atrioventricular blockade, arterial hypotension.
Treatment: symptomatic, involving a reduction in dose or drug withdrawal.
Interaction:With the simultaneous use of the drug with aminophylline, insulin secretion is enhanced.
Strengthens the effectiveness of anti-aggregation drugs (dipyridamole).
Weaken the action of vinblastine.
Special instructions:The drug is used for hepatic encephalopathy, conditions of acute and chronic intoxication with alcoholism. Used to restore liver function due to pronounced hepatotropic action.