Glutargin alkocline (Glutargin alkoclin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceArginine glutamateArginine glutamate
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    • Dosage form: & nbsppills
    Composition:

    In 1 tablet:

    active ingredient: arginine glutamate (in terms of 100% substance) 1.0 g.

    Excipients: cellulose microcrystalline (MCC 101) 0.110 g, crospovidone 0.020 g, calcium stearate 0.010 g.

    Description:Tablets are white, biconvex, oblong with a risk.
    Pharmacotherapeutic group:Hepatoprotective agent
    ATX: & nbsp

    A.05.B.A   Preparations for the treatment of liver diseases

    Pharmacodynamics:

    Glutargin alkoklin is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of the highly toxic metabolite of nitrogen metabolism - ammonia.Has a hepatoprotective effect, possessing antioxidant, antihypoxic and membrane-stabilizing activity, positively affects the energy supply in hepatocytes.

    When alcohol intoxication Glutargin alkoklin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol - alcohol dehydrogenase; accelerates inactivation and elimination of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the inhibitory effect of alcohol on the CNS due to the neurotransmitter properties of the excitatory glutamic acid.

    Glutargin alkoklin does not exert embryotoxic, gonadotoxic and mutagenic effects, does not cause allergic and immunotoxic reactions.

    Pharmacokinetics:Not studied.
    Indications:

    Reducing the symptoms of alcohol intoxication and withdrawal symptoms, including for preventive purposes.

    Prevention of hepatotoxic effects of alcohol.

    Contraindications:

    - hypersensitivity to drug components

    - children under 18 years of age

    - During pregnancy and breastfeeding

    Carefully:

    - febrile condition

    - increased excitability

    - severe violations of the filtration (nitrogen excretory) function of the kidneys (creatinine clearance less than 30 ml / min)

    Dosing and Administration:

    The drug is prescribed to adults inside regardless of food intake.

    To prevent intoxication and hepatotoxic action of alcohol, 2 tablets (2 g) are prescribed for 1-2 hours prior to alcohol intake or 1 tablet (1 g) for 1 h before alcohol intake and 1 tablet (1 g) for 0.5 h after reception of alcohol.

    Side effects:

    Seldom can there be a feeling of mild discomfort in the epigastric region and nausea immediately after using the drug, which pass on their own.

    Overdose:

    Symptoms: nausea, vomiting, pain in the chest, discomfort in the epigastric region, insomnia, transient short-term decrease in blood pressure, atrioventricular blockade, allergic reactions.

    Treatment: symptomatic, if necessary, taking antihistamines, in severe cases - intravenous glucocorticosteroids.

    Interaction:

    Care should be taken when Glutargin is combined with the following medicines:

    Aminophylline increases the concentration of endogenous insulin in the blood under the influence of Glutargin alcocline. Glutargin alkoklin can enhance the effect of antiplatelet agents (dipyridamole , etc.), prevents and weakens neurotoxic phenomena that can occur with isoniazid therapy, weakens the effect of vinblastine.

    Special instructions:When appointing patients with impaired functions of the endocrine glands, it should be taken into account that the drug may slightly increase the secretion of insulin and growth hormone, which does not require correction of medical therapy in patients with diabetes mellitus and / or acromegaly.
    Effect on the ability to drive transp. cf. and fur:

    The drug does not affect the ability to drive vehicles.

    Form release / dosage:

    Tablets 1 g.

    Packaging:1 or 10 tablets in a planar cell package. 2 contour packs per 1 tablet or 1 circuit cell pack of 10 tablets together with instructions for medical use in a pack of cardboard.
    Storage conditions:

    Keep in dry the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-000064
    Date of registration:03.12.2010 / 13.01.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine
    Manufacturer: & nbsp
    Information update date: & nbsp01.05.2017
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