Glutargin alkoklin - instructions for use, dose, side effects, contraindications

Glutargin alkoklin is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of the highly toxic metabolite of nitrogen metabolism - ammonia.Has a hepatoprotective effect, possessing antioxidant, antitoxic and membrane-stabilizing activity, positively affects the energy supply in hepatocytes.

When alcohol intoxication Glutargin alkoklin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol - alcohol dehydrogenase; accelerates inactivation and elimination of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the inhibitory effect of alcohol on the CNS due to the neurotransmitter properties of the excitatory glutamic acid.

Glutargin alkoklin does not exert embryotoxic, gonadotoxic and mutagenic effects, does not cause allergic and immunotoxic reactions.

Pharmacokinetics:Not studied.

Indications:

Prevention of alcohol intoxication and hepatotoxicity. Treatment of acute alcohol intoxication of mild and moderate severity, as well as in the complex therapy of post-toxication disorders after acute severe alcohol poisoning.

Contraindications:

- hypersensitivity to drug components

- children under 18 years of age

- During pregnancy and breastfeeding

- phenylketonuria, since the drug contains aspartame

Carefully:

- febrile condition

- increased excitability

- severe violations of the filtration (nitric acid) kidney function (creatinine clearance less than 30 ml / min)

Dosing and Administration:

The drug is prescribed to adults inside, regardless of food intake, previously dissolving the package in 1 / 4-1 / 2 cups of water.

To prevent intoxication and hepatotoxic action of alcohol, 2 packets (2 g of arginine of glutamate) are prescribed 1-2 hours prior to alcohol intake or 1 packet (1 g of glutamate arginine) 1 h before alcohol intake and 1 packet (1 g of glutamate arginine) for 0,5 h after taking alcohol.

For the treatment of acute alcohol intoxication of mild and moderate severity, 1 packet (1 g of arginine of glutamate) is administered 4 times a day at intervals of 1-2.5 h, in the following 2-3 days - 1 packet (1 g of arginine glutamate) 2 times per day. For severe alcohol poisoning, after a course of intravenous administration of Glutargin, 1 packet (1 g arginine of glutamate) of Glutargin alkoklin is prescribed 2 times a day for 20 days as part of complex therapy.

Side effects:

Seldom can there be a feeling of mild discomfort in the epigastric region and nausea immediately after using the drug, which pass on their own.

Overdose:

Symptoms: nausea, vomiting, pain in the chest, discomfort in the epigastric region, insomnia, transient short-term decrease in blood pressure, atrioventricular blockade, allergic reactions.

Treatment: symptomatic, if necessary, taking antihistamines, in severe cases - intravenous glucocorticosteroids.

Interaction:

Care should be taken when Glutargin is combined with the following medicines:

Aminophylline increases the concentration of endogenous insulin in the blood under the influence of Glutargin alcocline. Glutargin alkoklin can enhance the effect of antiplatelet agents (dipyridamole , etc.), prevents and weakens neurotoxic phenomena that can occur with isoniazid therapy, weakens the effect of vinblastine.

Special instructions:

When appointing patients with impaired functions of the endocrine glands, it should be borne in mind that the drug may slightly increase secretion insulin and growth hormone, which does not require correction of drug therapy in patients with diabetes mellitus and / or acromegaly.

Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles.

Form release / dosage:

Powder for solution for oral administration 1.0 g.

Packaging:3 g powder (1 g arginine glutamate) in the package (No. 1) or in paired packages (No. 2); two, five or ten packages (No. 1) or five paired packages (No. 2) in a pack of cardboard.

Storage conditions:

Store in the original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-000063

Date of registration:02.12.2010 / 12.01.2016

Expiration Date:Unlimited

The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine

Manufacturer: & nbsp

HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine

Information update date: & nbsp01.05.2017

Illustrated instructions

Instructions

Glutargin alkocline (Glutargin alkoclin)