The drug Glutargin is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralizing and removing from the body a highly toxic metabolite of nitrogen metabolism - ammonia. Hypoammonemic effects of the drug are realized by activating the elimination of ammonia in the ornithine cycle of urea synthesis,binding of ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system and its excretion from the body. As a result, general toxic, including neurotoxic, effects of ammonia are reduced.
The drug Glutargin has a hepatoprotective effect, possessing antioxidant, antihypoxic and membrane-stabilizing activity, positively influences the energy supply in hepatocytes.
When alcohol intoxication drug Glutargin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol - alcohol dehydrogenase; accelerates inactivation and elimination of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the inhibitory effect of alcohol on the CNS due to the neurotransmitter properties of the excitatory glutamic acid.
In the pathology of pregnancy due to endothelium-protective action, the drug Glutargin reduces the impaired permeability and thrombore resistance of blood vessels, prevents hypercoagulation, reduces the sensitivity of the vessels to vasoconstrictors (endothelium, angiotensin, thromboxane),causing generalized vasospasm. Arginine after preliminary biotransformation into nitric oxide has a vasodilating effect, positively affects the blood coagulation and the functional properties of the circulating elements of the blood. As a result of vasodilator and antihypoxic effects of the drug Glutargin, fetoplacental hemodynamics improves, intrauterine hypoxia of the fetus decreases. In the pathology of pregnancy, the drug also exhibits antitoxic and hepatoprotective activity, acts as a nonspecific metabolic regulator of metabolic processes. Due to these properties of the drug Glutargin during pregnancy, the level of immune complexes circulating in the blood decreases, the severity of the syndrome of "metabolic" intoxication and immunotoxicosis decreases, the compensatory-adaptive reactions of the organism increase. The drug Glutargin has no embryotoxic, gonadotoxic, mutagenic and teratogenic effects, does not cause allergic and immunotoxic reactions.