Bendazole (Bendazol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBendazoleBendazole
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    • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:

    Composition for 1 ml.

    Active substance: bendazole hydrochloride (in terms of bendazole) - 10.0 mg;

    Excipients: ethyl alcohol 95 % - 0.1 ml, glycerol (glycerol) in terms of 100% substance - 108 mg, hydrochloric acid solution 0.1M - up to pH 3.0, water for injection - up to 1.0 ml.

    Description:Colorless or slightly colored transparent liquid.
    Pharmacotherapeutic group:Vasodilator
    ATX: & nbsp

    C.04.A.X   Other peripheral vasodilators

    Pharmacodynamics:

    Spasmolytic agent of myotropic action. Has spasmolytic effect on all smooth muscles of blood vessels and internal organs, dilates blood vessels. Reduces blood pressure by reducing cardiac output and expanding peripheral vessels. Hypotensive activity is very moderate, and the effect is short-lived. With intramuscular injection, the hypotensive effect occurs within 30-60 minutes, and with intravenous administration for 15-20 minutes. The duration of the action is 2-3 hours.

    Pharmacokinetics:Studies have not been conducted.
    Indications:

    The drug is used for spasms of smooth muscles of internal organs (stomach ulcer, spasms of the gatekeeper and intestine), hypertensive crisis.

    Contraindications:

    Hypersensitivity to the drug; diseases accompanied by increased muscle tone or convulsive syndrome, children under 18 years of age (efficacy and safety not established).

    If you have one of the listed diseases (conditions), before taking the drug always consult a doctor.

    Carefully:

    Elderly age (reduction of cardiac output).

    Pregnancy and lactation:

    Because there is no safety data for the fetus, it can not be used during pregnancy. In the period of breastfeeding, if necessary, the drug Bendazole, you should stop breastfeeding for the duration of treatment with the drug.

    Dosing and Administration:

    Enter intravenously and intramuscularly.

    With hypertensive crisis injected intravenously or intramuscularly 30-40 mg (3-4 ml of a 10 mg / ml solution).

    Simultaneously with the drug Bendazole it is also possible to use other antihypertensive drugs.

    With spasms of smooth muscles the drug is administered intramuscularly at a dose of 10-20 mg (1-2 ml of a 10 mg / ml solution).

    Side effects:

    When used in large doses - dizziness, headache, heat, increased sweating, nausea.

    When the dose is lowered or the drug is withdrawn, these side effects quickly disappear.

    Allergic reactions are possible.

    If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

    Overdose:

    Symptoms: information on cases of overdose are absent.The most likely adverse event may be a marked decrease in blood pressure.

    Treatment: at the expressed decrease in arterial pressure to give to the patient a position "lying" with the raised lower extremities, to spend symptomatic therapy.

    Interaction:

    Bendazole prevents beta-adrenergic blockers caused by an increase in total peripheral vascular resistance. With the simultaneous use of bendazole and phentolamine, the hypotensive effect of bendazole is enhanced.

    Bendazol enhances the hypotensive effect of antihypertensive and diuretic drugs.

    Special instructions:

    The preparation contains ethanol and its content in a single dose may exceed 100 mg.

    Effect on the ability to drive transp. cf. and fur:

    During the treatment it is not recommended to drive vehicles, as well as engage in activities that require concentration of attention and speed of psychomotor reactions (see section "Special instructions").

    Form release / dosage:Solution for intravenous and intramuscular injection, 10 mg / ml.
    Packaging:

    To 2 ml in glass syringes of neutral glass with Luer Lock lock, with a hard cap and accessories.1 syringe per contour cell packaging made of polyvinyl chloride or polyethylene terephthalate film. On 1 contour acheikova packing together with a needle injecting and the instruction on application in a pack from cardboard box.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    The drug should not be used after the expiry date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-004601
    Date of registration:20.12.2017
    Expiration Date:20.12.2022
    The owner of the registration certificate:FARMZASCHITA NPC, FSUE FARMZASCHITA NPC, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.01.2018
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