Dibasol (Dibazol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBendazoleBendazole
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    • Dosage form: & nbspSolution for intravenous and intramuscular injection.
    Composition:

    Active substance: Bendazole (in terms of 100 % substance) - 10 mg

    Excipients: 0.1 M hydrochloric acid solution - 0.01 ml, glycerol (glycerin) - 108 mg, ethanol (ethyl alcohol) 96% - 0.1 ml, water for injection - up to 1 ml.

    Description:Transparent colorless liquid with a specific odor.
    Pharmacotherapeutic group:Vasodilating agent.
    ATX: & nbsp

    C.04.A.X   Other peripheral vasodilators

    Pharmacodynamics:

    Spasmolytic agent of myotropic action.Has spasmolytic effect on smooth muscles of blood vessels and internal organs, dilates blood vessels. Reduces blood pressure by reducing cardiac output and expanding peripheral vessels. Hypotensive activity is very moderate, and the effect is short-lived. With intramuscular injection, the antihypertensive effect occurs within 30 to 60 minutes, with intravenous administration during 15-20 minutes. The duration of the action is 2-3 hours.

    Pharmacokinetics:

    Studies have not been conducted.

    Indications:

    The drug is used for spasms of smooth muscles of the internal organs (peptic ulcer, spasms of the gatekeeper and intestines), hypertensive crises.

    Contraindications:

    Hypersensitivity to bendazole and other components of the drug; diseases accompanied by increased muscle tone or convulsive syndrome, children under 18 years of age.

    Carefully:

    Elderly age (reduction of cardiac output).

    Pregnancy and lactation:

    As there is no data on the safety of the dibazol preparation for the fetus, it can not be used during pregnancy.During lactation, the issue of stopping breastfeeding during the treatment with Dibazol should be resolved.

    Dosing and Administration:

    The drug is administered intravenously and intramuscularly.

    With hypertensive crisis - intravenously and intramuscularly 30 - 40 mg (3 - 4 ml of a solution of 10 mg / ml).

    Simultaneously with Dibazol, other antihypertensive medications can also be used.

    With spasms of smooth muscles - intramuscularly 10 - 20 mg (1 - 2 ml of a solution of 10 mg / ml).

    Side effects:

    From the central nervous system: dizziness, slight headache.

    From the digestive system: nausea.

    Local reactions (at the site of administration): local soreness.

    Other: increased sweating, a feeling of heat, allergic reactions.
    Overdose:No information.
    Interaction:

    Bendazole prevents beta-adrenergic blockers caused by an increase in total peripheral vascular resistance. With the simultaneous use of bendazole and phentolamine, the antihypertensive effect of bendazole is enhanced.

    Bendazol enhances the antihypertensive effect of antihypertensive and diuretic drugs.

    Special instructions:It is not recommended to appoint for long-term treatment of hypertension, especially to elderly patients, since the antihypertensive effect is associated with a decreasecardiac output and possibly a worsening of the electrocardiogram.
    Effect on the ability to drive transp. cf. and fur:

    During treatment, it is not recommended to drive vehicles, as well as engage in activities that require speed of psychomotor reactions and precise movements.

    Form release / dosage:

    Solution for intravenous and intramuscular injection 10 mg / ml.

    Packaging:

    1 ml, 2 ml or 5 ml into neutral glass ampoules.

    For 10 ampoules, together with the instructions for use and a knife for an opened ampoule or ampoule scapegrifier, is placed in a box of cardboard

    5 ampoules per contour cell packaging made of polyvinyl chloride film.

    2 contoured cell packs together with instructions for use and a knife for opening ampoules or a scarifier ampullum are placed in a pack of cardboard.

    When using ampoules with break points, incisions, rings, a knife for opening ampoules or an ampoule scarifier is allowed not to be put.

    Storage conditions:

    In the dark place at a temperature of 2 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years. Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-001560
    Date of registration:02.04.2012
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp02.04.2012
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