Dibasol (Dibazol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceBendazoleBendazole
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    • Dosage form: & nbspSolution for intravenous and intramuscular injection.
    Composition:Active substance:
    Bendazole hydrochloride (dibazol) - 10 mg
    Excipients:
    Ethanol 95% (ethyl alcohol) - 0.1 ml;
    Glycerol (glycerin distilled in terms of 100%) - 108 mg;
    1 M hydrochloric acid solution - 0.001 ml;
    Water for injection - up to 1 ml.
    Description:Transparent colorless liquid with a specific odor.
    Pharmacotherapeutic group:Vasodilating agent.
    ATX: & nbsp

    C.04.A.X   Other peripheral vasodilators

    Pharmacodynamics:

    Spasmolytic agent of myotropic action. Has spasmolytic effect on all smooth muscles of blood vessels and internal organs, dilates blood vessels. Reduces blood pressure by reducing cardiac output and expanding peripheral vessels. Hypotensive activity is very moderate, and the effect is short-lived. With intramuscular injection, the hypotensive effect occurs within 30-60 minutes, and with intravenous administration for 15-20 minutes. The duration of the action is 2-3 hours.

    Pharmacokinetics:Studies have not been conducted.
    Indications:

    The drug is used for spasms of smooth muscles of internal organs (stomach ulcer, spasms of the gatekeeper and intestine), hypertensive crisis.

    Contraindications:

    Hypersensitivity to the drug; disease. accompanied by increased muscle tone or convulsive syndrome, children under 18 years of age (efficacy and safety not established).

    Carefully:

    Elderly age (reduction of cardiac output).

    Pregnancy and lactation:

    Because there is no safety data for the fetus, it can not be used during pregnancy.In the period of breastfeeding, if you need to use the drug Dibazol, you should stop breast-feeding for the duration of treatment with the drug.

    Dosing and Administration:

    Enter intravenously and intramuscularly.

    With hypertensive crisis injected intravenously or intramuscularly 30-40 mg (3-4 ml of a 10 mg / ml solution).

    Simultaneously with Dibazolum it is possible to apply also other hypotensive medicines.

    With spasms of smooth muscles the drug is administered intramuscularly at a dose of 10-20 mg (1-2 ml of a 10 mg / ml solution).

    Side effects:

    When used in large doses - dizziness, headache, heat, increased sweating, nausea.

    When the dose is lowered or the drug is withdrawn, these side effects quickly disappear. Allergic reactions are possible.

    Overdose:

    Symptoms: There is no information about overdose cases. The most likely adverse event may be a marked decrease in blood pressure.

    Treatment: with a marked reduction in blood pressure, give the patient lying "position with raised lower limbs, to carry out symptomatic therapy.

    Interaction:

    Bendazol prevents the increase in total peripheral vascular resistance caused by beta - adrenoblockers. With the simultaneous use of bendazole and phentolamine, the hypotensive effect of bendazole is enhanced.

    Bendazol enhances the hypotensive effect of antihypertensive and diuretic drugs.

    Special instructions:The preparation contains ethanol and its content in a single dose may exceed 100 mg.
    Effect on the ability to drive transp. cf. and fur:

    During treatment is not recommended the management of vehicles, as well as engaging in activities that require concentration and speed of psychomotor reactions (cm. section "Special instructions ").

    Form release / dosage:

    Solution for intravenous and intramuscular injection 10 mg / ml.

    Packaging:

    1, 2, 5 ml into neutral glass ampoules.

    For 10 ampoules with instructions for use and a knife ampoule or scarifier ampoule placed in a box of cardboard.

    5 or 10 ampoules are placed in a contoured cell pack of a polyvinyl chloride film or a polyethylene terephthalate tape and aluminum foil, or paper with a polyethylene coating, or without a foil, or without paper.

    For 1 or 2 contour squares with instructions for use and a vial ampoule or scarifier ampullum placed in a pack of cardboard.

    When you pack the ampoules with a break ring or break point, the ampoule knife or ampoule scapegrator is not inserted.

    Storage conditions:

    At a temperature of 2 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years. Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-002454
    Date of registration:06.05.2014
    The owner of the registration certificate:NOVOSIBHIMFARM, OJSC NOVOSIBHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp06.05.2014
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