The drug is intended for intramuscular, intravenous, subcutaneous, endolumbic and intratracheal administration.
In case of moderate disease (lower respiratory tract infections, urine and bile ducts, soft tissue infections, etc.), 4-6mln ED / day for 4 injections.
In severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units per day; with gas gangrene - up to 40-60 million units.
The daily dose for children under the age of 1 year is 50000-100000 units / kg, over 1 year - 50000 units / kg; if necessary - 200000-300000 units / kg, according to vital indications - increase to 500000 units / kg. Multiplicity of administration - 4-6 times a day, intravenously - 1-2 times a day in combination with intramuscular injections.
Endolumbally administered with purulent diseases of the brain and spinal cord and meninges.
Depending on the disease and the severity of its course: adults - 5-10 thousand units, children - 2-5 thousand units once a day for 2-3 days intravenously, then prescribed intramuscularly.
For intravenous fluid administration a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9 % solution of sodium chloride and injected slowly, for 3-5 minutes.
For intravenous drip 2-5 million ED are diluted with 100-200 ml of a 0.9% solution of sodium chloride or 5-10 % solution of dextrose and injected at a rate of 60-80 cap / min.
When drip introduction to children as a solvent use a 5-10% solution of dextrose (100-300 ml, depending on the dose and age).
Solution of the drug for intramuscular injection are prepared immediately before administration, adding to the contents of the vial 1-3 ml of water for injection or 0.9% solution of sodium chloride or 0.5% solution of novocaine.
The solutions are used immediately after preparation, not allowing the addition of other drugs to them.
Subcutaneously the drug is used to cut infiltrates in a concentration of 100-200 thousand units per ml of 0.25-0.5% solution of novocaine.
Preparation of the drug solution for endolumbal application: diluted in sterile water for injection or in 0.9 % solution of sodium chloride at a rate of 1 thousand units / ml.
Before injection (depending on intracranial pressure), 5-10 ml of cerebrospinal fluid is extracted and added to the antibiotic solution in equal proportions. Enter slowly (1 ml / min), usually 1 time per day for 2-3 days, then go to intravenous or intramuscular injection.
When suppuration processes in the lungs, a drug solution intratrahealno (after careful anesthesia of throat, larynx and trachea). Usually 100 thousand units are used in 10 ml of 0.9 % solution of sodium chloride.
In case of eye diseases (acute conjunctivitis, corneal ulcers, gonoblenaire, etc.), appoint eye drops, containing 20-100 thousand units in 1 ml of a 0.9% solution of sodium chloride or distilled water. Enter 1-2 drops 6-8 times a day.
For ear drops or drops in the nose apply solutions containing 10-100 thousand units / ml.Duration of treatment with the drug, depending on the form and severity of the course of the disease - from 7-10 days to 2 months or more (for example, with sepsis, septic endocarditis).