Intravenous, intramuscular, subcutaneous.
Intravenous and intramuscular: with moderate infections of the upper and lower respiratory tract, urinary and bile ducts, soft tissue infections, etc. - 2.5-5 million units per day for 4 injections. In severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units per day; with gas gangrene - up to 40-60 million units per day.
The daily dose for children under the age of 1 year is 50000-100000 units / kg, over 1 year - 50000 units / kg; if necessary - 200000-300000 units / kg, according to "vital" indications - increase - up to 500000 units / kg. Multiplicity of administration - 4-6 times a day, intravenously 1-2 times a day in combination with intramuscular injections.
Subcutaneously for chipping infiltrates in a concentration of 100,000-200,000 units per ml of 0.25-0.5% procaine solution.
In case of eye diseases: eye drops in the concentration of 20000-100000 units in 1 ml of a 0.9% solution of sodium chloride or distilled water, 1-2 drops 6-8 times a day. Duration of treatment with the drug, depending on the form and severity of the course of the disease - 7-10 days.
Method of preparation of solutions
Solution of the drug for intramuscular injection are prepared immediately before administration, adding to the contents of the vial 1-3 ml of water for injection or 0.9% solution of sodium chloride or 0.5% of the solution of procaine.
When diluting benzylpenicillin in a procaine solution, cloudiness of the solution may occur due to the formation of crystals benzylpenicillin procaine, which is not an obstacle for intramuscular and subcutaneous administration of the drug.
For intravenous fluid administration a single dose of 1-2 million units is dissolved in 5-10 ml of water for injection or 0.9% solution of sodium chloride and injected slowly, within 3-5 minutes.
For intravenous drip 2-5 million ED are diluted with 100-200 ml of 0.9% sodium chloride solution or 5-10% dextrose solution and injected at a rate of 60-80 cap / min.When drip introduction to children as a solvent used 5-10% solution of dextrose (30-100 ml, depending on the dose and age).
The solutions are used immediately after preparation, not allowing the addition of other drugs to them.
Solution for topical application in ophthalmology should be prepared ex tempore: Dissolve the contents of the vial in a 0.9% solution of sodium chloride or distilled water: 500,000 units in 5-25 ml, 1000000 units in 10-50 ml, respectively.