Benzylpenicillin sodium salt is injected in / m, iv. With intravenous and intramuscular injection, single doses for moderate to severe infections of the upper and lower divisions of the respiratory tract, urinary and bile ducts, infections of soft tissues, etc. are - 250,000 - 500,000 units 4 times a day. In severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units per day; with gas gangrene - up to 40-60 million units per day.
The daily dose for children under the age of 1 year is 50000-100000 units / kg, over 50000 U / kg over 1 year, 200000-300000 U / kg if necessary, and for "vital" indications - an increase to 500000 U / kg. Multiplicity of administration - 4-6 times a day, intravenously 1-2 times a day in combination with intramuscular injections.
The drug solution for intramuscular injection is prepared immediately before administration, adding to the contents of the vial 1-3 ml of water for injection or a solution of sodium chloride isotonic 0.9% or 0.5% solution of novocaine.
For intravenous administration, a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9% solution NaCl and injected slowly, within 3-5 minutes.
For intravenous drip injection of 2-5 million units, dilute 100-200 ml of a 0.9% solution NaCl or 5-10% dextrose solution and injected at a rate of 60-80 cap / min. When drip introduction to children as a solvent used 5-10% solution of dextrose (30-100 ml, depending on the dose and age). The solutions are used immediately after preparation, not allowing the addition of other drugs to them.
The duration of treatment with benzylpenicillin, depending on the form and severity of the course of the disease - 7-10 days.