Benzylpenicillin sodium salt is administered intramuscularly, intravenously, subcutaneously, topically.
Intravenous and intramuscular: with moderate disease (upper and lower respiratory tract infections, urinary and biliary tract infections, soft tissue infection, etc.) - 4-6 million units / day for 4 injections. In severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million ED / day; with gas gangrene - up to 40-60 million units / day.
The daily dose for children under the age of 1 year - 50-100 thousand units / kg, over the year A - 50 thousand units / kg; if necessary - 200-300 thousand units / kg, according to "vital" indications - an increase to 500 thousand units / kg.Multiplicity of administration: intramuscularly - 4-6 times a day, intravenously 1-2 times a day in combination with intramuscular injections.
Subcutaneously for the cutting of infiltrates in a concentration of 100-200 thousand units per ml of 0.25-0.5% solution of procaine.
In the cavity (abdominal, pleural, etc.) solution of benzylpenicillin sodium salt to adults is administered at a concentration of 10-20 thousand units in 1 ml, children - 2-5 thousand units in 1 ml. As the solvent is used water for injections, or 0,9 % solution of sodium chloride. Duration of treatment is 5-7 days with the subsequent transition to intramuscular injection.
With eye diseases appoint eye drops, containing 20-100 thousand units in 1 ml of a sterile 0.9% solution of sodium chloride or distilled water. Enter 1-2 drops 6-8 times a day. The solution is used freshly prepared.
For the ear drops or drops in the nose apply solutions containing 10-100 thousand units in 1 ml sterile, 0.9% sodium chloride solution or distilled water. Enter 1-2 drops 6-8 times a day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the course of the disease - 7-10 days.
The solutions are used immediately after preparation, not allowing the addition of other drugs to them.
For intramuscular injection to the contents of the bottle add 1-3 ml of water for injection, 0.9% solution of sodium chloride or 0.5% solution of procaine (novocaine). The resulting solution is injected deep into the muscle.
When diluting benzylpenicillin in a procaine solution, cloudiness of the solution may occur due to the formation of crystals benzylpenicillin procaine, which is not an obstacle for intramuscular and subcutaneous administration of the drug.
For intravenous fluid administration a single dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9 % solution of sodium, chloride and injected t slowly, within 3-5 minutes.
For intravenous drip 2-5 million ED are diluted in 100-200 ml of 0.9 % solution of sodium chloride or 5-10% solution of dextrose and injected at a rate of 60-80 cap / min. When drip introduction to children as a solvent used 5-10% solution of dextrose (30-100 ml, depending on the dose and age).
For subcutaneous administration the contents of the vial are diluted in 0.25-0.5 % solution of procaine: 500 thousand units in 2.5-5 ml, 1 million units in 5-10 ml, respectively.
For intracavitary administration the contents of the vial are diluted in 0.9% solution of sodium chloride or in water for injections: adults - 500 thousand.ED in 25-50 ml, 1 million units in 50-100 ml respectively; children - 500 thousand units in 100-250 ml, 1 million units in 200-500 ml respectively.
Eye drops should be prepared ex tempore: the contents of the bottle are diluted in 0.9% solution of sodium chloride or distilled water: 500 thousand units in 5-25 ml, 1 million units in 10-50 ml, respectively.
Ear drops and drops in the nose: the contents of the bottle are diluted in 0.9% solution of sodium chloride or distilled water: 500 thousand units in 5-50 ml, 1 million units in 10-100 ml, respectively.