Active substanceMetamizol sodium + Pitofenone + Fentpiverinia bromideMetamizol sodium + Pitofenone + Fentpiverinia bromide
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  • Dosage form: & nbsppills
    Composition:

    Each tablet contains:

    Active substances:

    metamizole sodium - 500 mg

    Pitophenone hydrochloride - 5 mg

    fenpiperinium bromide - 0.1 mg

    Excipients: lactose, corn starch (anhydrous), povidone, methylhydroxybenzoate, talc purified, magnesium stearate.

    Description:

    Pale yellow round, flat pills with bevelled edges, risky on one side and engraved "MICRO" - on the other side.

    Pharmacotherapeutic group:Analgesic agent (analgesic non-narcotic remedy + antispasmodic)
    ATX: & nbsp

    N.02.B.B.52   Metamizole sodium in combination with other drugs, excluding psycholeptics

    Pharmacodynamics:

    Metamizol sodium (analgin) has analgesic, antipyretic and weak anti-inflammatory effect. Pitophenone hydrochloride, like papaverine, has a direct myotropic effect on the smooth muscles of the internal organs and causes it to relax. Fentipierinium bromide due to m-holinoblokiruyuschego action has an additional antispasmodic effect on smooth muscle.

    Indications:

    Pain syndrome with spasms of smooth muscles of internal organs - renal and biliary colic, intestinal spasms, algodismenorea and other spastic conditions of internal organs, as well as headache and mngrenorrhoeal pain. Can be used for short-term symptomatic treatment for arthralgia, neuralgia, ischialgia, myalgia.

    As an adjuvant can be used to reduce pain after surgical and diagnostic interventions.

    Contraindications:

    Hypersensitivity to pyrazolone derivatives (butadione) and to other components of the drug; granulocytopenia, marked violations of the liver or kidney; deficiency of glucose-6-phosphate dehydrogenase; tachyarrhythmia, acute "intermittent" porphyria; closed-angle form of glaucoma; hyperplasia of the prostate; intestinal obstruction and megacolon; diseases of the blood system; collaptoid states; pregnancy (first trimester and the last 6 weeks); lactation period; children's age (up to 5 years); increased individual sensitivity to non-steroidalanti-inflammatory drugs or non-narcotic analgesics.

    Carefully:

    With caution and under the supervision of a doctor, the drug should be administered to patients with impaired liver or kidney function, with a tendency to hypotension, bronchospasm. Children and adolescents (up to 18 years of age) should use the drug only as directed by a doctor.

    Pregnancy and lactation:Contraindicated.
    Dosing and Administration:

    Adults and children over 15 years of age take inside (preferably after eating) usually 1-2 tablets 2-3 times a day. The daily dose should not exceed 6 tablets. Duration of reception - no more than 5 days. An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

    Dosage for children. Children should be given the drug only as prescribed by the doctor. Dosage for children 5-7 years - half the tablet, 8-12 years - three quarters of the tablet, 13-15 years - one tablet 2-3 times a day. Other dosage regimens are possible only after consultation with a physician.

    Side effects:

    In therapeutic doses, the drug is usually well tolerated. Sometimes allergic reactions are possible (skin rash, itching, very rarely anaphylactic shock).In rare cases - a burning sensation in the epigastric region, dry mouth, headache. Possible - dizziness, lower blood pressure, tachycardia, cyanosis. With long-term admission - cases of violation of the blood system (thrombocytopenia, leukopenia, agranulocytosis). With propensity to bronchospasm may provoke an attack. In very rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), decreased sweating, accommodation paresis, urinary retention. Rarely (usually with prolonged administration or administration of high doses) - a violation of kidney function: oliguria, anuria, proteinuria, interstitial nephritis, staining the urine in red.

    All side effects should be reported to your doctor.

    Overdose:

    Symptoms: vomiting, lowering blood pressure, drowsiness, confusion, nausea, pain in the epigastric region, impaired liver and kidney function, convulsions. Treatment: gastric lavage, the appointment of activated charcoal, symptomatic therapy.

    Interaction:

    The simultaneous use of Brala® with other non-narcotic analgesics may lead to mutualstrengthening effects. Tricyclic antidepressants, oral contraceptives, allopurinol disrupt metamizole metabolism in the liver and increase its toxicity. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium. Simultaneous use with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the analgesic effect of the drug. When combined with ethanol - mutual enhancement of effects. If you need to use these and other medications at the same time, you should consult your doctor.

    Special instructions:

    During the treatment with the drug, you should not take alcohol. Use in nursing mothers requires the cessation of breastfeeding. With prolonged (more than 5 days) use of the drug, control of the picture of peripheral blood and the functional state of the liver is necessary.

    Effect on the ability to drive transp. cf. and fur:It is not recommended to drive vehicles and engage in other potentially hazardous activities requiring quick physical and mental response.
    Form release / dosage:

    Pills.

    Packaging:

    For 10 tablets in a PVC / aluminum blister or an aluminum strip.

    For 1, 2 or 10 blisters or strips together with instructions for use in a pack of cardboard.

    10 blisters or strips along with 10 instructions for use in a pack of cardboard.

    Storage conditions:

    In a dry, dark place, out of the reach of children, at a temperature of no higher than 25 ° C.

    Shelf life:5 years. Do not use after the time specified on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:П N012121 / 01
    Date of registration:23.08.2010 / 22.07.2014
    Expiration Date:Unlimited
    The owner of the registration certificate:Micro Labs LimitedMicro Labs Limited India
    Manufacturer: & nbsp
    Representation: & nbspMICRO LABS LIMITED MICRO LABS LIMITED India
    Information update date: & nbsp21.02.2017
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