Simultaneous use of Spazgan with other non-narcotic analgesics may lead to mutual enhancement of toxic effects. Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium.
Simultaneous use with cyclosporine reduces the level of the latter in the blood.
Sedatives and tranquilizers increase the analgesic effect of metamizole sodium.
When co-appointed with Hi-gistaminoblockers, butyrophenones, phenothiazines, amantadine and quinidine, M-cholinolytic action may be enhanced.
When combined with ethanol - mutual enhancement of effects. The simultaneous use of chloropropromazine or other phenothiazine derivatives may lead to the development of severe hyperthermia. Radiopaque drugs and colloid blood substitutes should not be used during treatment with drugs containing metamizol sodium.
Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, can increase the severity of their action.
Thiamazole and cytostatics increase the risk of developing leukopenia.
The effect is enhanced codeine, H2-gistaminoblockers and propranolol (slows the inactivation of metamizole sodium).
The solution for injection is pharmaceutically incompatible with other drugs.
If you need to use these and other medications at the same time, you should consult your doctor.