The frequency of development and severity of side effects depend on the duration of application, the amount of dose used and the possibility of observing the circadian rhythm of the appointment.
Disorders from the endocrine system: decreased glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, oppression of the adrenal gland function, Itenko-Cushing syndrome (lunar face, obesity of the pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis,"steroid" stria), delayed sexual development in children.
Violations of the blood and lymphatic system: mild leukocytosis, lymphopenia, eosinopenia, polycythemia.
Disorders from the gastrointestinal tract: nausea, vomiting, pancreatitis, steroid ulcer of the stomach and duodenum, erosive esophagitis, bleeding and perforation of the stomach or intestines, increase or decrease in appetite, flatulence, hiccough, abdominal pain, discomfort in the stomach. In rare cases - increased activity of "liver" transaminases and alkaline phosphatase.
Violations from the heart and blood vessels: arrhythmias, bradycardia (up to cardiac arrest); development (in predisposed patients) or worsening of the course of chronic heart failure; changes in the electrocardiogram, characteristic of hypokalemia; increased blood pressure, hypercoagulation, thrombosis; with intravenous administration: "hot flashes" to the face, vasculitis, increased fragility of capillaries. In patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
Disorders of the psycheNervousness or anxiety, insomnia, emotional instability, delirium, confusion, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia, suicidal.
Disturbances from the nervous system: increased intracranial pressure, dizziness, headache, vertigo, pseudotumor cerebellum, convulsions.
Disturbances on the part of the organ of sight: Sudden loss of vision (when administered parenterally in the head, neck, nasal turbinate, the scalp may be the deposition of crystals of the drug in the blood vessels of the eye), posterior subcapsular cataracts, increased intraocular pressure with possible damage to the optic nerve, the propensity to develop secondary bacterial, fungal or viral eye infections, trophic changes cornea, exophthalmos, chemosis, ptosis, mydriasis, corneal perforation, central serous chorioretinopathy.
Disorders from the metabolism and nutrition: Hypercholesterolemia, increased excretion of calcium, hypocalcemia, increase of body weight, negative nitrogen balance (increased protein breakdown), increased sweating, epidural lipomatosis.
Caused by mineralocorticoid activity - fluid retention and sodium (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).
Disturbances from musculoskeletal and connective tissue: slowing growth and ossification processes in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and thigh bone), rupture of the tendons of the muscles, steroid myopathy, muscle loss (atrophy).
Disorders from the kidneys and urinary tract: leukocyturia.
Disturbances from the skin and subcutaneous tissues: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, "steroid" acne, steroid striae, propensity to develop pyoderma and candidiasis, rosace-like perioral dermatitis, suppression of reactions during skin tests, telangiectasia, hypertrichosis.
Immune system disorders: generalized (skin rash, skin itching, anaphylactic shock), local allergic reactions.
Infectious and parasitic diseases: development or exacerbation of infections (the emergence of this side effect is facilitated by jointly used immunosuppressants and vaccination).
General disorders and disorders at the site of administration: withdrawal syndrome, local with parenteral administration: burning, numbness, pain, paresthesia and infections at the injection site, rarely - necrosis of surrounding tissues, scar formation at the injection site; atrophy of the skin and subcutaneous tissue with the / m introduction (especially dangerous is the introduction to the deltoid muscle).