The frequency of development and severity of side effects depend on the duration of application, the amount of dose used and the possibility of observing the circadian rhythm of the appointment.
Disorders from the endocrine system: a decrease in glucose tolerance, "Steroid" diabetes or a manifestation of latent diabetes mellitus, adrenal suppression, Cushing's syndrome (moon face, obesity, pituitary type, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, myasthenia gravis, "steroid" striae) delayed sexual development in children.
Disturbances from the hematopoiesis system: moderate leukocytosis, lymphopenia, eosinopenia, polycythemia.
Disorders from the digestive system: nausea, vomiting, pancreatitis, steroid ulcer of stomach and duodenum, erosive esophagitis, bleeding and perforation of the stomach or intestines, increase or decrease in appetite, flatulence, hiccough, abdominal pain, discomfort in the stomach. In rare cases - increased activity of "liver" transaminases and alkaline phosphatase.
Heart Disease: arrhythmias, bradycardia (up to cardiac arrest); development (in predisposed patients) or increased severity of CHF; changes in the electrocardiogram, characteristic of hypokalemia. In patients with acute and subacute myocardial infarction - the spread of the focus of necrosis, slowing the formation of scar tissue, which can lead to rupture of the heart muscle.
Vascular disorders: increased blood pressure, hypercoagulation, thrombosis; with iv introduction: "tides" of blood to the face, vasculitis, increased fragility of capillaries.
Impaired nervous system: increased intracranial pressure, nervousness or anxiety, insomnia, dizziness, vertigo, pseudotumor cerebellum, headache, convulsions, emotional lability.
Disorders from the psyche: delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, depression, paranoia.
Impaired sensory organs: sudden loss of vision (with parenteral administration in the area of the head, neck, nasal concha, scalp may deposition of drug crystals in the vessels of the eye); posterior subcapsular cataract; increased intraocular pressure with possible damage to the optic nerve; propensity to develop secondary bacterial,fungal or viral infections of the eyes; trophic changes of the cornea; exophthalmos; chemosis, ptosis, mydriasis, perforation of the cornea.
Disorders from the metabolism: increased excretion of Ca2+, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating.
Caused by mineralocorticoid activity - fluid retention and Na+ (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).
Epidural lipomatosis.
Disturbances from the musculoskeletal and connective tissue: slowing the growth and processes of ossification in children (premature closure of epiphyseal growth zones), osteoporosis (very rarely - pathological bone fractures, aseptic necrosis of the head of the humerus and thigh bone), rupture of muscle tendons, steroid myopathy, muscle loss (atrophy).
Disturbances from the skin and mucous membranes: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, "steroid" acne, steroid striae, propensity to develop pyoderma and candidiasis, rosace-like perioral dermatitis, suppression of reactions during skin tests.
Immune system disorders: generalized (skin rash, skin itching, anaphylactic shock) and local allergic reactions.
Disorders from the urinary system: leukocyturia.
Infectious and parasitic diseases: development or exacerbation of infections (the emergence of this side effect is facilitated by jointly used immunosuppressants and vaccination).
General disorders and disorders at the site of administration: withdrawal syndrome; burning, numbness, pain, paresthesia and infection at the injection site, rarely - necrosis of surrounding tissues, scar formation at the injection site; atrophy of the skin and subcutaneous tissue with the / m introduction (especially dangerous is the introduction to the deltoid muscle).