DONA® (DONA®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGlucosamineGlucosamine
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    • Dosage form: & nbspfilm coated tablets
    Composition:

    One tablet contains:

    active substance: glucosamine sulfate crystalline 942 mg (equivalent to glucosamine sulfate 750 mg and sodium chloride 192 mg);

    Excipients: cellulose microcrystalline 68 mg, povidone K 25 (polyvinylpyrrolidone K 25) 45 mg, croscarmellose sodium 20 mg, macrogol 6000 (polyethylene glycol 6000) 15 mg, magnesium stearate 8.50 mg, talc 1.50 mg; shell: methacrylic acid and methyl methacrylate copolymer [1: 1] (Eudragit L 12.5) 1.0 mg, titanium dioxide, ground 11.50 mg, talc 10.55 mg, methyl methacrylate, trimethylammonioethyl methacrylate chloride and ethyl acrylate copolymer [2: 0.2:1 ] (Eudragit RL 30 D) 4.50 mg, triacetin (glycerol triacetate) 0.90 mg, macrogol 6000 (polyethylene glycol 6000) 0.55 mg.

    Description:

    The tablets covered with a cover, white color, oblong. On the cross section, two layers are visible: the outer white, the inner one white with a brownish tinge.

    Pharmacotherapeutic group:Reparation of tissue stimulant
    ATX: & nbsp

    M.01.A.X.05   Glucosamine

    Pharmacodynamics:

    DONA® has an anti-inflammatory and analgesic effect, replenishes the endogenous deficiency of glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. It promotes the fixation of sulfur during the synthesis of chondroitinsulfuric acid, facilitates the normal deposition of calcium in the bone tissue, inhibits the development of degenerative processes in the joints, restores their function, reducing joint pain.

    Pharmacokinetics:

    Absorption in the gastrointestinal tract 90%, bioavailability 25 %, the elimination half-life is 70 hours.

    Indications:Osteoarthritis of peripheral joints and spine, osteochondrosis.
    Contraindications:

    Individual hypersensitivity to the active substance and other components of the drug, severe chronic renal failure. It is not recommended to administer the drug during pregnancy and lactation, and also in childhood (up to 12 years) because of the lack of scientific clinical data in this category of patients.

    Carefully:

    Care should be taken in patients with allergies to seafood (shrimp, shellfish). The drug contains 75.5 mg of sodium in a pill, which should be taken into account for patients who follow a controlled sodium diet.

    Take care with bronchial asthma and diabetes.
    Pregnancy and lactation:Not recommended prescription of the drug during pregnancy and lactation due to the lack of scientific clinical data in this category of patients.
    Dosing and Administration:

    Inside. For 1 tablet 750 mg taken orally 2 times a day preferably while eating, with a glass of water. The symptomatic effect occurs 2-3 weeks after the application of the drug. The minimum course of therapy is 4-6 weeks.

    If necessary, the course of treatment is repeated at intervals of 2 months.Duration and treatment scheme is appointed by the attending physician.

    Side effects:

    Drug tolerance is good, in some cases, possible: gastralgia, flatulence, nausea, diarrhea, constipation; headache, drowsiness; allergic reactions - erythema, urticaria, pruritus.

    Overdose:

    Cases of overdose are unknown. Treatment: gastric lavage, symptomatic therapy.

    Interaction:

    Compatible with non-steroidal anti-inflammatory drugs, paracetamol and glucocorticosteroids. Increases the absorption of tetracyclines, reduces - semisynthetic penicillins, chloramphenicol; enhances the effect of coumarin anticoagulants.

    Special instructions:

    When using the drug in patients with impaired glucose tolerance, with severe hepatic and renal insufficiency, medical control is necessary.

    Effect on the ability to drive transp. cf. and fur:Absent.
    Form release / dosage:

    Film-coated tablets, 750 mg.

    Packaging:

    For 60 or 180 tablets in a polyethylene bottle with a snap-on lid, along with the instructions for use, are placed in a cardboard box.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date stated on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001932
    Date of registration:18.12.2012
    The owner of the registration certificate:Rottafarm SpARottafarm SpA Italy
    Manufacturer: & nbsp
    Madaus, GmbH Germany
    Representation: & nbspROTTAFARM SPAROTTAFARM SPARussia
    Information update date: & nbsp19.11.2015
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