Elkar - instructions for use, doses, side effects, contraindications

Composition:Active ingredient: Levocarnitine (Carnifit) 300 mg; Excipients: Citric acid monohydrate 1.2 mg methyl parahydroxybenzoate 0.5 mg propyl parahydroxybenzoate 0.2 mg Purified water to 1 ml.

Description:

Transparent colorless or slightly colored liquid.

A specific odor is allowed.

Pharmacotherapeutic group:Metabolic means

ATX: & nbsp

A.16.A.A Amino acids and their derivatives

A.16.A.A.01 Levocarnitine

Pharmacodynamics:

L-carnitine - a natural substance, related to vitamins of group B.Participates in metabolic processes as a carrier of long-chain fatty acids (palmitic, etc.) from the cytoplasm in the mitochondria where these acids are subjected to the process of [3-oxidation with the formation of adenosine triphosphoric acid and acetyl-CoA. It improves protein and fat metabolism, increases secretion and enzymatic activity of gastric and intestinal juices, improves digestion, reduces excess body weight and reduces fat content in muscles. Increases resistance to physical stress, inhibits the formation of keto acids and anaerobic glycolysis, reduces the degree of lactic acidosis, promotes the economical consumption of glycogen and increases its stores in the liver and muscles.

Has an anabolic and lipolytic effect. Normalizes the increased basal metabolism in hyperthyroidism: it is a peripheral (indirect) antagonist of the action of thyroid hormones, and not a direct inhibitor of thyroid function.

Improves metabolism and energy supply of tissues.

Pharmacokinetics:

Well absorbed in the intestine, the concentration in the blood plasma reaches a maximum after 3 hours and remains in the therapeutic range for 9 hours. Easily penetrates into the liver, myocardium, more slowly - into the muscles.It is excreted by the kidneys, mainly in the form of acyl esters.

Indications:

The drug is used as part of complex therapy.

- intensive physical exertion and psychoemotional stress: to increase efficiency, endurance, reduce fatigue, including in the elderly;

- in the period of rehabilitation after the transferred diseases and surgical interventions, traumas, including, to accelerate the regeneration of tissues;

- complex therapy of chronic gastritis and chronic pancreatitis with a decreased secretory function;

- complex therapy of skin diseases (psoriasis, seborrheic eczema, focal scleroderma and discoid lupus erythematosus);

- hyperthyroidism of mild degree;

- neurologic manifestations in vascular, toxic and traumatic brain lesions;

- a syndrome of anorexia nervosa;

- diseases accompanied by a deficiency of carnitine or its increased loss (myopathies, cardiomyopathies, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency) - to make up for its deficiency in the composition of complex therapy;

- in pediatric practice (treatment of children under 3 years under the supervision of a doctor): when nursing preterm infants, newborns who have suffered a trauma or asphyxia; Children with sluggish sucking reflex and low weight gain; reduced muscle tone, with insufficient development of motor and mental functions, as well as to prevent these disorders in children at risk; with growth retardation and lack of body weight in children and adolescents under 16 years.

- in adults in sports medicine and in intensive training (during the training process in the training of aerobic performance): to improve speed and strength and coordination of movements, to increase muscle mass and reduce body fat, to prevent post-training syndrome (acceleration of recovery processes after physical loads), with traumatic injuries in order to accelerate the regeneration of muscles.

Contraindications:

Individual intolerance.

Pregnancy and lactation:

In connection with the lack of research, use during pregnancy and lactation is not recommended.

Dosing and Administration:

The drug is used as part of complex therapy.

Inside 30 minutes before meals, additionally diluted with liquid.

With prolonged physical and psychoemotional loads: from 0.75 g (1/2 measuring spoon or 2.5 ml) 3 times a day to 2.25 grams (1.5 scoops or 7.5 ml) 2-3 times a day.

With anorexia nervosa, as well as during rehabilitation after the transferred diseases and surgical interventions and injuries: on 1,5 g (1 measuring spoon or 5 ml) 2 times a day. The course of treatment - within 1-2 months.

In the complex therapy of chronic gastritis and chronic pancreatitis with a decreased secretory function: on 0,375 g (1/4 of a measuring spoon or 1,25 ml) 2 times a day. The course of treatment is within 1-1.5 months.

For the treatment of skin diseases: by 0.75 g (1/2 measuring spoon or 2.5 ml). The course of treatment is within 2-4 weeks.

For hyperthyroidism of mild degree: on 0.25 g (13 drops) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after 1-2 months break or appointed for 3 months without interruption.

In vascular, toxic and traumatic brain lesions: on 0,75 g (1/2 measuring spoon or 2,5 ml) per day. The course of treatment is within 3-5 days. If necessary, after 12-14 days, appoint a second course.

In diseases accompanied by a deficiency of carnitine (primary and secondary carnitine insufficiency): up to 50-100 mg / kg (2-5 drops / kg) of body weight with a frequency of reception 2-3 times a day. The course of treatment - for 3-4 months.

Children Appoint as an additive to sweet dishes (jelly, compote, juices). For children up to 3 years, the dose is determined by the attending physician. From 3 to 6 years - in a single dose of 0.1 g (5 drops) 2-3 times a day, in a daily dose of 0.2-0.3 g (11-16 drops). The course of treatment - 1 month. Children from 6 to 12 years are prescribed a single dose of 0.2-0.3 g (11-16 drops) 2-3 times a day, at a daily dose of 0.4-0.9 g (22-48 drops). The course of treatment - at least 1 month.

If growth is delayed: on 0.25 g (13 drops) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after 1-2 months break or appointed for 3 months without interruption.

In sports medicine and intensive training: 2.5 grams 1-3 times a day (daily dose 2.5 -7.5 g); in the case of use with a therapeutic purpose, 70-100 mg / kg / day (5-7.5 g / day). Admission courses: 3-4 weeks in pre-contest period. During the training process - up to 6-8 weeks.

Side effects:

Possible allergic reactions, gastralgia, dyspepsia, myasthenia gravis (in patients with uremia).

Overdose:

Symptoms: dyspeptic disorders, myasthenic disorders (in patients with uremia).

Treatment: gastric lavage, reception of activated charcoal.

Interaction:

Glucocorticosteroids contribute to the accumulation of the drug in tissues (except the liver), other anabolics enhance the effect.

Special instructions:Treatment of children under the age of 3 years is carried out under the supervision of a doctor.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the performance of potentially hazardous activities requiring special attention and quick reactions (driving and other vehicles, working with moving mechanisms, dispatcher and operator work, etc.).

Form release / dosage:

Solution for oral administration 300 mg / ml.

Packaging:

100 ml glass bottle. To 100 ml in bottles of dark glass, sealed with caps with a control ring of the first opening. A measuring cup with a volume of 20 ml is put on the bottle. Each bottle, together with the instructions for use, is placed in a pack of cardboard.

50 ml glass bottle. To 50 ml in bottles of dark glass, ukuporennyh caps with droppers with a control ring of the first dissection. Each bottle, along with a measuring spoon with a nominal volume of 5 ml with risks labeled "1/4" and "1/2" (corresponding to 1.25 ml and 2.5 ml), is placed in a pack of cardboard with instructions for use.

25 ml glass bottle. To 25 ml in bottles of dark glass, ukuporennyh caps with droppers with a control ring of the first opening. Each bottle, together with the instructions for use, is placed in a pack of cardboard.

25 ml plastic bottle. For 25 ml in plastic bottles, sealed with lids with a control ring of the first opening, 10 or 20 plastic bottles along with the instruction for use are placed in a packet with cardboard partitions.

Storage conditions:In a place protected from light and inaccessible to children at a temperature of no higher than 25 ° C. After opening - in the refrigerator for 2 months.

Shelf life:

3 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-006143/10

Date of registration:30.06.2010

The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia

Manufacturer: & nbsp

PIC-PHARMA PRO, LLC Russia

VIPS-MED, LLC Russia

Information update date: & nbsp13.10.2015

Illustrated instructions

Instructions

Elkar® (Elcar®)