Nefrokarnit - instructions for use, dose, side effects, contraindications

Excipients: sorbitol solution 70% 480.0 mg, hydrochloric acid solution 36% 9.0 mg, methyl parahydroxybenzoate 3.0 mg, propyl parahydroxybenzoate 1.7 mg, purified water 2129.7 mg.

Description:A clear, colorless solution.

Pharmacotherapeutic group:Metabolic means

ATX: & nbsp

A.16.A.A Amino acids and their derivatives

A.16.A.A.01 Levocarnitine

Pharmacodynamics:

Nephrodynamics is a means for correcting metabolic processes; has metabolic, anabolic, antihypoxic and antithyroid action, activates fat metabolism, stimulates tissue regeneration.

The active substance of the drug - levocarnitine is a biological amine that is a cofactor of metabolic processes, participates in metabolic processes as a carrier of fatty acids through cellular membranes from the cytoplasm to the mitochondria, where these acids are oxidized with the formation of a large amount of energy.

Levokarnitin normalizes protein and fat metabolism, increases secretion and enzymatic activity of gastric and intestinal juices, improves digestion of food, reduces excess body weight, restores alkaline blood reserve, inhibits the formation of keto acids and anaerobic glycolysis, reduces lactic acidosis, normalizes increased basal metabolism in hyperthyroidism: peripheral (indirect) antagonist action of thyroid hormones, and not a direct inhibitor of thyroid function, and also increases motor activity five and improves exercise tolerance.

Pharmacokinetics:

The oral bioavailability of Levocarnitine is mainly dose dependent and is almost 100% at low (physiological) doses. The concentration in the blood plasma reaches a maximum after 3 hours after oral administration and remains in the therapeutic range for 9 hours.

Levokarnitin is rapidly distributed in the body, mainly accumulating in the liver, heart and skeletal muscles. Levocarnitine in any concentration does not bind to plasma proteins.

Levokarnitin in a small degree is metabolized and excreted through the kidneys.

Indications:

The drug is used as part of complex therapy with:

- intensive physical and psychoemotional stresses: to increase efficiency, endurance, reduce fatigue, including in the elderly;

- during rehabilitation after the transferred diseases and surgical interventions, traumas, including to accelerate the regeneration of tissues;

- complex therapy of chronic gastritis and chronic pancreatitis with a decreased secretory function;

- complex therapy of skin diseases (psoriasis, seborrheic eczema, focal scleroderma and discoid lupus erythematosus);

- mild hyperthyroidism;

- neurological manifestations in vascular, toxic and traumatic brain lesions;

- Anorexia nervosa syndrome;

- diseases accompanied by a deficiency of carnitine or its increased loss (myopathies, cardiomyopathies, mitochondrial diseases, hereditary diseases with concomitant mitochondrial insufficiency) - to fill its deficiency in the complex therapy;

- in pediatric practice (treatment of children under 3 years under the supervision of a doctor): when nursing preterm infants, newborns who have suffered a trauma or asphyxia; children with sluggish sucking reflex and low weight gain, reduced muscle tone, with insufficient development of motor and mental functions, and also for the purpose of preventing these disorders in children at risk; with growth retardation and lack of body weight in children and adolescents under 16;

- in adults in sports medicine and in intensive training to improve speed and strength and coordination of movements, to increase muscle mass and reduce body fat, to prevent post-training syndrome (accelerate recovery processes after physical exertion),with traumatic injuries in order to accelerate the regeneration of muscles.

Contraindications:

Hypersensitivity to the active substance or to any of the excipients, intolerance to fructose, pregnancy, lactation.

If you have any of the above conditions, consult your doctor.

Pregnancy and lactation:

See section Contraindications.

Dosing and Administration:

Inside.

For convenience of dosing, you can use a beaker that is in the preparation's packaging, a pipette or a medical syringe. One measuring beaker contains 3.3 ml of the preparation. The preparation can be further diluted with liquid.

With primary and secondary carnitine deficiency:

50 - 100 mg / kg (2-5 drops of the drug / kg) of body weight with a frequency of 2-3 times a day. The course of treatment is within 3-4 months.

Children Appoint as an additive to sweet dishes (jelly, compote, juices). For children up to 3 years, the dose is determined by the attending physician.

Children from 3 to 6 years - in a single dose of 0.1 g (5 drops) 2-3 times a day. The course of treatment is 1 month.

Children from 6 to 12 years of age, the drug is prescribed in a single dose of 0.2 - 0.3 g (11 - 16 drops) 2 - 3 times a day. The course of treatment - at least 1 month.

If growth is delayed: on 0.25 g (13 drops) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after 1 - 2 months break or appointed for 3 months without interruption.

With prolonged physical and psychoemotional loads: from 0.75 g (2.5 ml of the preparation) 3 times a day to 2.25 g (7.5 ml of the preparation) 2-3 times a day.

With anorexia nervosa, as well as during rehabilitation after the transferred diseases and surgical interventions and injuries: on 1,5 g (5 ml of preparation) 2 times a day. The course of treatment is within 1 to 2 months.

In the complex therapy of chronic gastritis and pancreatitis with a decreased secretory function: for 0.375 g (1.25 ml of the preparation) 2 times a day. Course of treatment - during 1-1,5 months.

For the treatment of skin diseases: for 0.75 g (2.5 ml of the drug) per day. The course of treatment is within 2-4 weeks.

For hyperthyroidism of mild degree: for 0.25 g (13 drops of the drug) 2-3 times a day. The course of treatment is 20 days. The course of treatment is repeated after 1 - 2 months break or prescribe the drug for 3 months without interruption.

With vascular, toxic and traumatic brain lesions: for 0.75 g (2.5 ml of the drug) per day. The course of treatment is within 3-5 days. If necessary, through 12-14 days appoint a second course.

In sports medicine and intensive training: 2.5 grams 1 to 3 times a day; in case of use with a therapeutic purpose, 70-100 mg / kg / day (5 - 7.5 g / day). Admission courses: 3-4 weeks in the pre-contest period. During the training process - up to 6 - 8 weeks.

Side effects:

Pain in epigastrium, dyspepsia, allergic reactions, myasthenia gravis (in patients with uremia).

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Dyspeptic disorders, myasthenic disorders (in patients with uremia).

Treatment: gastric lavage, reception of activated charcoal.

Interaction:

Glucocorticosteroids contribute to the accumulation of the drug in tissues (except for the liver), anabolic drugs enhance the effect of levocarnitine. Pivalat increases the rate of removal of Levocarnitine through the kidneys.

Special instructions:

Treatment of children under the age of 3 years is carried out under the supervision of a doctor. Patients with fructose intolerance should not use this medication.

The nephrodynamics, the solution for ingestion contains preservatives: methylparahydroxybenzoate andpropyl parahydroxybenzoate, which can cause allergic reactions (possibly delayed).

Only a clear solution should be used without mechanical impurities. If changes occur in the solution, such as turbidity, sedimentation, discoloration, the solution is not suitable for use and must be destroyed.

Effect on the ability to drive transp. cf. and fur:

Levokarnitin does not affect the concentration of attention and can be used by people managing vehicles, machines and mechanisms.

Form release / dosage:

Solution for oral administration 1 g / 3.3 ml.

Packaging:

50 ml in a brown glass flask (type 3) with polyethylene dropper, polypropylene beaker and polypropylene screw cap. The bottle is placed in a cardboard box with instructions for use.

Storage conditions:

In dry, the dark place at a temperature of 5^aboutС to 25^aboutC. Keep the bottle tightly closed, out of the reach of children.

Shelf life:

3 years (after the bottle is opened, the shelf life is 3 months).

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003368

Date of registration:17.12.2015

Expiration Date:17.12.2020

Date of cancellation:2016-12-07

The owner of the registration certificate:Meditsa Artznamittel Pütter GmbH & Co. KG. KGMeditsa Artznamittel Pütter GmbH & Co. KG. KG Germany

Manufacturer: & nbsp

MEDICE ARZNEIMITTEL PUTTER, GmbH & Co. KG. KG Germany

Information update date: & nbsp07.12.2016

Illustrated instructions

Instructions

Nephrocaritoneum (Nephrocarnite)