The drug Fangiflu should be taken internally. Adults, with cryptococcal infections, candidemia, disseminated candidiasis, other invasive candidiasis infections, 400 mg are prescribed on day 1, then 200-400 mg once a day. The duration of treatment depends on the clinical and mycological response (with cryptococcal meningitis is at least 6-8 weeks).
For the prevention of cryptococcal meningitis in AIDS patients, therapy at a dose of 200 mg per day can be continued for a long time.
With oropharyngeal candidiasis - 50-100 mg once a day for 7-10 days, in patients with immunosuppression -14 days or more.
To prevent the recurrence of oropharyngeal candidiasis in AIDS patients after completing the full course of primary therapy - 150 mg once a week.
At atrophic oral candidiasis, associated with the wearing of dentures; - 50 mg once a day for 14 days in combination with local antiseptic drugs for prosthesis treatment.
With other candidiasis of the mucous membranes (with the exception of genital candidiasis) - 50-100 mg per day, the duration of treatment - 14-30 days.
With vaginal candidiasis - 150 mg once. To reduce the frequency of relapses, once a month, 150 mg are used for 4-12 months, sometimes more frequent use may be required.
With balanitis caused by Candida, 150 mg per day once.
For the prevention of candidiasis, the recommended dose of the drug is 50-400 mg per day, depending on the degree of risk of fungal infection. If there is a high risk of generalized infection, for example, in patients with expected severe or persistent neutropenia, the recommended dose is 400 mg per day. The drug Fangiflu is prescribed several days before the expected appearance of neutropenia; after an increase in the number of neutrophils more than 1 thousand / μl treatment is continued for another 7 days.
For skin lesions, including foot mycoses, inguinal skin, and candidiasis - 150 mg once a week or 50 mg once a day, the duration of treatment is 2-4 weeks (up to 6 weeks with foot mycoses).
With pityriasis 300 mg once a week for 2 weeks, some patients require a third dose of 300 mg per week, while in some cases it is sufficient to take a single dose of 300-400 mg; an alternative treatment regimen is to administer 50 mg once a day for 2-4 weeks.
With onychomycosis - 150 mg once a week; Treatment continues until the infected nail is replaced. For the repeated growth of nails on the fingers and toes, it normally takes 3-6 months and 6-12 months, respectively.
At deep endemic mycoses - 200-400 mg per day for up to 2 years. The duration of therapy is determined individually; it can be 11-24 months with coccidioidomycosis, 2-17 months with paracoccidioidomycosis, 1-16 months with sporotrichosis and 3-17 months with histoplasmosis.
In children, as with similar infections in adults, the duration of treatment depends on the clinical and mycological effect. In children, the drug should not be used in a daily dose that would exceed that of adults. The drug is used daily 1 time per day (use special dosage forms for children).
Children with esophageal candidiasis are prescribed 3 mg / kg per day once infor at least 3 weeks and within 2 weeks after the regression of the symptoms; at candidiasis of mucous membranes - 3 mg / kg per day once for at least 3 weeks; in the treatment of generalized candidiasis and cryptococcal infection (including meningitis) - 6-12 mg / kg per day for 10-12 weeks (before laboratory confirmation of the absence of pathogens in the cerebrospinal fluid).
For the prevention of fungal infections in children with reduced immunity, the risk of infection is associated with neutropenia, resulting from cytotoxic chemotherapy or radiation therapy, 3-12 mg / kg per day, depending on the severity and duration of preservation of induced neutropenia.
For newborn infants, the interval between injections is 72 hours, for children 2-4 weeks of age, the same dose is administered at intervals of 48 hours.
In children with impaired renal function, the daily dose of the drug should be reduced (in the same proportional relationship as in adults) according to the degree of renal insufficiency. In elderly patients in the absence of violations of kidney function should follow the usual dosage regimen.Patients with renal impairment (creatinine clearance less than 50 mL / min) dosing regimen should be adjusted as indicated below.
In chronic renal failure initially introduced "shock" dose of 50-400 mg with CC 50 mL / min designate usual daily dose with CC 11-50 ml / min - 50% of the recommended dose or usual dose of 1 to 2 times of the day; patients undergoing hemodialysis, - 1 dose after each dialysis.