Fluconazole in the form of a solution for injection is injected intravenously at a rate of no more than 20 mg (10 ml) / min. When transferring from intravenous administration to taking capsules and vice versa, there is no need to change the daily dose.
The infusion solution is compatible with the following solvents: 20% glucose solution, Ringer's solution, Hartman's solution, potassium chloride solution in glucose, 4.2% bicarbonate sodium solution, aminofusin, isotonic sodium chloride solution.
Infusions of fluconazole can be carried out using conventional transfusion kits using one of the liquids listed above.
Application in adults.
In cryptococcal infections, the usual dose of fluconazole is 400 mg once a day on the first day of treatment, later on - 200-400 mg once a day. The duration of treatment for cryptococcal infections depends on the clinical efficacy, confirmed by mycological examination; usually varies from 6 to 8 weeks.
To prevent the recurrence of cryptococcal meningitis in AIDS patients after completing the full course of primary therapy
fluconazole appoint a patient in doses of at least 200 mg / day for a long period.
With candidemia, disseminated candidiasis and other invasive, candidal infections, the daily dose is 400 mg on the first day and 200 mg on subsequent days. Depending on the clinical effectiveness of the drug, the dose can be increased to 400 mg / day. The duration of treatment depends on clinical effectiveness.
In oropharyngeal candidiasis, including patients with impaired immunity, the usual dose is 50-100 mg once a day for 7-14 days. If necessary, the treatment can be prolonged, especially with severe immunity disorders.
In other candidiasis infections, for example, with esophagitis, noninvasive bronchopulmonary infections, candiduria, candidiasis of the skin and mucous membranes, the usual daily dose is 50-100 mg for 14-30 days.
For the prevention of fungal infections in patients with malignant neoplasms, the dose
fluconazole but should be 50 mg once a day as long as the patient is at high risk because of cytostatic therapy or radiation therapy.
Use in children.
As with similar infections in adults, the duration of treatment depends on the clinical and mycological effect. For children, the daily dose of the drug should not exceed that of adults.
Fluconazole apply daily once a day.
In candidiasis of mucous membranes, the recommended dose of fluconazole is
3 mg / kg / day. On the first day, in order to achieve the steady-state equilibrium concentrations more quickly, a shock dose of 6 mg / kg can be administered.
For the treatment of generalized candidiasis and cryptococcal infection, the recommended dose is 6-12 mg / kg / day, depending on the severity of the disease.
For the prevention of fungal infections in patients with depressed immunity, which the risk of infection is associated with neurophenia, which develops as a result of cytotoxic chemotherapy or radiation therapy, the drug is prescribed at 3-12 mg / kg / day, depending on the severity and duration of preservation of induced neurosy (see dosage for adults, for children with kidney failure - see dosage with renal insufficiency.)
Use in children aged 4 weeks or less.
In newborns
fluconazole output slowly. In the first 2 weeks of life the drug is prescribed in the same dose (mg / kg) as for older children, but at an interval of 72 hours. Children at the age of 3 and 4 weeks of life are administered the same dose at intervals of 48 hours.
Application in the elderly
In the absence of impaired renal function, the usual dosage recommendations should be followed. For patients with impaired renal function (creatinine clearance <50 mL / min), the dosage regimen should be adjusted as indicated below.Use in patients with renal insufficiency.
Fluconazole is excreted primarily through the kidneys in an unchanged form. With a single admission dose changes are not required. In patients (including children) with impaired renal function, when taking the drug again, a "shock" dose of 50 mg to 400 mg should be initially administered. After the introduction of the "shock" dose, the daily dose (depending on the indication) is determined according to the following table:
| Creatinine clearance (ml / min) | Percent recommended dose |
| >50 | 100% |
| <50 (without dialysis) | 50% |
| Patients permanently on dialysis | 100% after each dialysis session |