Intravenously in the form of infusion at a rate of not more than 20 mg (10 ml) / min. When transferring from intravenous administration to taking capsules and vice versa, there is no need to change the daily dose.
The infusion solution is compatible with the following solvents: 20% dextrose solution, Ringer's solution, Hartman's solution, potassium chloride solution in dextrose, 4.2% sodium bicarbonate solution, 0.9% sodium chloride solution.
Flucosan infusions can be performed with conventional transfusion kits using one of the above fluids.
Application in adults
In cryptococcal infections, the usual dose of Flukosan is 400 mg once a day on the first day of treatment, then 200-400 mg once a day. The duration of treatment for cryptococcal infections depends on the clinical efficacy, confirmed by mycological examination; usually varies from 6 to 8 weeks.
For the prevention of cryptococcal meningitis in AIDS patients after completion of the full course of primary treatment, Flukosan 200 mg per day is prescribed for a long period.
With candidemia, disseminated candidiasis and other invasive candidiasis infections, the daily dose of Flucosan is 400 mg on the first day and 200 mg on subsequent days. Depending on the clinical effectiveness of the drug, the dose can be increased to 400 mg per day.The duration of treatment depends on clinical effectiveness.
With oropharyngeal candidiasis, including patients with impaired immunity, the usual dose of Flukosan is 50-100 mg once a day for 7-14 days. To prevent the recurrence of oropharyngeal candidiasis in AIDS patients after completing the full course of primary therapy - 150 mg once a week. If necessary, the treatment can be prolonged, especially with severe immunity disorders.
With vaginal candidiasis, 150 mg once. To reduce the relapse rate, once a month, 150 mg every 4-12 months, sometimes more frequent use may be required.
In other candidiasis infections, for example, with esophagitis, noninvasive bronchopulmonary infections, candiduria, the daily dose is 50-100 mg for 14-30 days.
For the prevention of fungal infections in patients with malignant formations, the dose of Flukosan is 50 mg once a day, until the patient is at high risk due to cytostatic therapy or radiation therapy.
Use in children
As with similar infections in adults, the duration of treatment depends on the clinical and mycological effect. In children, the drug should not be used in a daily dose exceeding that of adults.Flukozan is used daily once a day.
For the treatment of generalized candidiasis and cryptococcal infection, the recommended dose is 6-12 mg / kg per day, depending on the severity of the disease.
For the prevention of fungal infections in patients with reduced immunity the drug is prescribed at 3-12 mg / kg per day.
In newborns, Flucosan is more slowly excreted, therefore, in the first 2 weeks of life, the drug is given in the same dose (in mg / kg) as in older children, but at intervals of 72 hours. Children at the age of 3 and 4 weeks of life are administered the same dose at intervals of 48 hours.
Application in the elderly
In the absence of impaired renal function, the usual dosage recommendations should be followed. For patients with impaired renal function (creatinine clearance less than 50 ml / min), the dosage regimen should be adjusted as indicated below.
Use in patients with renal insufficiency
With a single admission Flukozan dose changes are not required. In patients (including children) with impaired renal function, when taking the drug again, a "shock" dose of 50 to 400 mg should be initially administered. After the introduction of the "shock" dose, the daily dose (depending on the indication) is determined according to the following table:
| Creatinine clearance | % recommended dose |
| >50 | 100% |
| <50 (without dialysis) | 50% |
| Patients permanently on dialysis | 100% after each dialysis |