Fluconazole (Fluconazole)

Inside.

Adults and children over 15 years of age (body weight over 50 kg), with cryptococcal meningitis and cryptococcal infections of other locations on the first day, usually prescribed 400 mg (8 capsules of 50 mg), and then continue treatment at a dose of 200 mg (4 capsules of 50 mg) - 400 mg (8 capsules of 50 mg) once a day.The duration of treatment for cryptococcal infections depends on the clinical efficacy, confirmed by mycological examination; when cryptococcal meningitis treatment course should be at least 6-8 weeks.

To prevent the recurrence of cryptococcal meningitis in AIDS patients, after completion of the full course of primary therapy, fluconazole prescribe a dose of 200 mg (4 capsules of 50 mg) per day for a long period of time.

When candidemia, disseminated candidiasis and other invasive candidiasis infections on the first day of the dose is 400 mg (8 capsules of 50 mg), and then - 200 mg (4 capsules of 50 mg) per day. With insufficient clinical efficacy, the dose of the drug can be increased to 400 mg (8 capsules 50 mg) per day. The duration of therapy depends on the clinical effectiveness of the drug (100% of the recommended dose). With SC from 11 to 50 ml / min 50% of the recommended dose or usual dose is applied once in 2 days.

Clearance	Interval / daily '
creatinine	; dose " ■ '
> 40 ml / min	24 h 1 (normal dosing regimen)
21-40 ml / min	48 hours (1 time in 2 days) or half the usual
	daily dose (once every 24 hours)
1 10-20 ml / min	72 hours (G every 3 days)

Patients regularly on dialysis,one dose of the drug is used after each session of hemodialysis. In oropharyngeal candidiasis, the drug is usually prescribed at 150 mg once a day, the duration of treatment is 7-14 days. If necessary, in patients with a pronounced decrease in immunity, treatment may be longer. For the prevention of recurrence of oropharyngeal candidiasis in AIDS patients after completing the full course of primary therapy, 150 mg once a week. In other cases of candidiasis (with the exception of the genital), for example, esophagitis, non-invasive bronchopulmonary injury, candiduria, candidiasis of the skin and mucous membranes, etc., the effective dose is usually 150 mg / day with a treatment duration of 14-30 days. For the prevention of candidiasis in a patient x with cancer the recommended dose of fluconazole amounts to 150-400 mg (3-8 capsules of 50 mg), 1 times a day depending on the degree of risk of fungal vaginal candidiasis infektsii.Pri fluconazole prescribe a dose of 150 mg (1 capsule of 150 mg or 3 capsules of 50 mg) once, inside. To reduce the frequency of recurrence of vaginal candidiasis -150 mg (1 capsule of 150 mg or 3 capsules of 50 mg) once a month for 4-12 months, sometimes you may need more frequent application. In candida balanitis - 150 mg (1 capsule of 150 mg or 3 capsules of 50 mg) once a day, once. For skin infections, including foot mycoses, inguinal skin and candidiasis, the recommended dose is 150 mg (1 capsule of 150 mg or 3 capsules 50 mg) once a week or 50 mg (1 capsule 50 mg) once a day, the dosing regimen depends on the clinical and mycological effect. The duration of therapy in usual cases is 2-4 weeks, however, with foot mycoses may require more long-term therapy (up to 6 weeks). In case of pityriasis - 300 mg (2 capsules of 150 mg or 6 capsules of 50 mg) once a week for 2 weeks, some patients require a third dose of 300 mg per week, while in some cases a single 300-400 mg dose is sufficient. With onychomycosis - 150 mg once a week; Treatment continues until the infected nail is replaced. To re-grow the nails on the fingers and toes, it normally takes 3-6 months and 6-12 months, respectively.