Furazolidone (Furazolidone)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceFurazolidoneFurazolidone
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    BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC     Republic of Belarus
  • Furazolidone
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    AVEKSIMA, JSC     Russia
  • Furazolidone
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    MARBIOFARM, OJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    1 tablet contains:

    Active substance - furazolidone 0.05 g

    Excipients - potato starch - 0.02 g

    calcium stearate (calcium stearic acid) 0.001 g

    sugar (sucrose) 0.01 g

    Tween-80 (polysorbate) -0,0002 g

    lactose (milk sugar) - 0.0188 g
    Description:

    Tablets of yellow or greenish-yellow color, flat-cylindrical with a facet.

    Pharmacotherapeutic group:Antimicrobial and antiprotozoal.
    ATX: & nbsp

    G.01.A.X.06   Furazolidone

    Pharmacodynamics:

    Antimicrobial agent derived from nitrofurans. It is active against gram-positive and gram-negative microbes, Trichomonas spp., Giardia Iambiia. Most sensitive to furazolidone Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi.

    Slightly affects the pathogens of purulent and anaerobic infection. Stability of microorganisms develops slowly. It blocks monoamine oxidase.

    Nitrofurans disrupt the processes of cellular respiration of microorganisms, inhibit the cycle of tricarboxylic acids (the Krebs cycle), and also inhibit the biosynthesis of nucleic acids of microorganisms, as a result of which their shell or cytoplasmic membrane breaks down.As a result of the action of nitrofurans, microorganisms produce fewer toxins, so that the improvement of the patient's general condition is possible even before the expressed suppression of microflora growth. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate the immune system of the body (increase the complement titre and the ability of leukocytes to phagocytose microorganisms).

    Pharmacokinetics:

    It is well absorbed by oral administration. Against the background of inflammation of the meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. Rapidly and extensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in the feces, where therapeutic concentrations are achieved against the causative agents of intestinal infections

    Indications:

    Dysentery, paratyphoid, giardiasis. food poisoning.

    Contraindications:

    Pregnancy, lactation. Increased individual sensitivity to the group of nitrofurans. Terminal stage of chronic renal failure, deficiency of glucose-b-dehydrogenase, children under 3 years (for this dosage form).

    Carefully:

    Chronic kidney failure, deficiency of glucose-6-phosphate dehydrogenase, liver and nervous system diseases.

    Dosing and Administration:

    Inside, after eating. With dysentery, paratyphoid and foodborne toxic infections - 100-150 mg 4 times a day (but not more than 800 mg), for 5-10 days.

    With giardiasis: adults - 100 mg 4 times a day, children - 10 mg / kg / day, distributing the daily dose for 3-4 doses. The highest single dose for adults is 200 mg; daily - 800 mg.

    Side effects:

    Decreased appetite, right up to anorexia; nausea, vomiting; allergic reactions (skin rash, hyperemia and itching of the skin, angioedema).

    With prolonged use - neuritis.

    Overdose:

    Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis). Treatment: cancellation of drugs, taking a lot of fluids, symptomatic therapy, antihistamines, vitamin B vitamins.

    Interaction:

    Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore, their simultaneous administration is not recommended.

    Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.

    Special instructions:

    Increases oppression of hematopoiesis against the background of chloramphenicol and ristomycin.

    Increases the sensitivity to the action of ethanol. Medicines, alkalinizing urine, reduce the effect, and acidifying - increase.

    Aminoglycosides and tetracycline enhance antimicrobial properties.

    During the treatment, precautions should be observed, as with monoamine oxidase inhibitors, namely: the exclusion from the diet of products containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

    For the prevention of neuritis with prolonged use it is necessary to combine with vitamins of group B.

    Form release / dosage:Tablets 50 mg.
    Packaging:

    Form of issue *

    Tablets 50 mg.

    10 tablets per contour without packaging or contour mesh packing.

    50 tablets per can of polymeric materials.

    By 2, 3. 4. 5 contour cell packs or 1 can of polymeric materials with instructions for medical use in a pack of cardboard.

    Contour non-cellular packages with an equal number of instructions for medical use, or packs of cardboard is placed in a group package.

    Form of issue **

    Tablets 50 mg.

    10 tablets per contour packing.

    50 tablets per can of polymeric materials.

    By 1, 2, 3. 4 or 5 contour mesh packages or 1 can of polymeric materials with instructions for medical use in a pack of cardboard.

    * - these sections are indicated in the Instruction on medical use for preparations manufactured at OJSC Irbitsky Chemical Pharmaceutical Plant.

    ** - these sections are indicated in the Instruction on medical use for preparations produced at OOO Anzhero-Sudzhensky Chemical and Pharmaceutical Plant.

    Storage conditions:

    List B. In dry the dark place. Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-004228/09
    Date of registration:28.05.2009
    The owner of the registration certificate:AVEKSIMA, JSC AVEKSIMA, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp12.11.2015
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