Active substanceFurazolidoneFurazolidone
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  • Furazolidone
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    DALHIMFARM, OJSC     Russia
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    AVEKSIMA, JSC     Russia
  • Furazolidone
    pills inwards 
    MARBIOFARM, OJSC     Russia
  • Dosage form: & nbsppills
    Composition:

    Active substance: furazolidone - 50 mg Excipients: potato starch, food gelatin, aerosil (silicon dioxide colloid), calcium stearate 1-water (calcium stearate monohydrate)

    Description:

    Tablets are yellow or greenish-yellow in color, flat-cylindrical shape with a bevel.

    Pharmacotherapeutic group:Antimicrobial and antiprotozoal drug-nitrofuran
    ATX: & nbsp

    G.01.A.X.06   Furazolidone

    Pharmacodynamics:

    The drug refers to antimicrobial and antiprotozoal drugs. Has bacteriostatic action against microbes. The mechanism of action is the violation of the activity of certain enzyme systems of bacteria. Spectrum of action: Gram-positive cocci (Streptococcus, Staphylococcus),

    gram-negative rods (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Of the causative agents of intestinal infections, the causative agents of dysentery, typhoid and paratyphoid are most sensitive. Sustainability develops slowly.

    Pharmacokinetics:

    When administered orally furazolidone slightly absorbed and inactivated in the intestine. Only about 5% of the drug is excreted in the urine in unchanged form or in the form of metabolites, while staining the urine in brown.

    Indications:

    Dysentery; paratyphuses; giardiasis, food poisoning; trichomonadal colpitis, urethritis; infected wounds and burns.

    Contraindications:

    Hypersensitivity, terminal stage chronic renal failure, pregnancy, lactation, children's age (up to 1 year).

    Carefully:

    Chronic renal failure, deficiency glucose-6-phosphate dehydrogenase, liver and nervous system diseases, it is necessary to abstain from alcohol intake during drug treatment due to possible interaction.

    Dosing and Administration:

    Furazolidone is prescribed inside.

    To treat paratyphoid, dysentery, food toxic infections adults take 100-150 mg after meals 4 times a day for 5-10 days (duration depends on the nature and severity of the pathological process). In the same doses furazolidone can be taken in cycles of 3-6 days (intervals of 3-4 days).

    Doses for children - 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    Furazolidone it is not recommended to appoint more than 10 days.

    In the treatment of giardiasis, adults take 100 mg of furazolidone 4 times a day, children - at a dose of 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    Higher daily intake for adults for oral administration: single dose - 200 mg, daily - 800 mg.

    Side effects:

    Perhaps the appearance of nausea, vomiting, decreased appetite; in some cases, allergic reactions may develop. To reduce side effects when using furazolidone it is recommended to take it before meals and drink the drug with plenty of liquid, if necessary, reduce the dose, prescribe antihistamines and B vitamins. If there are any side effects, stop using the drug.

    Overdose:

    Symptoms - acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

    Treatment - withdrawal of the drug, the intake of a large amount of fluid, symptomatic therapy, antihistamines, vitamin B vitamins.

    Interaction:

    Furazolidone is an inhibitor of monoamine oxidase; When it is used, the same precautions as with other monoamine oxidase inhibitors should be followed.

    Aminoglycosides and tetracyclines enhance the antimicrobial properties of furazolidone.

    Sensitizes the body to alcohol, it is possible to develop disulfiram-like reactions when used simultaneously with ethanol.

    Furazolidone increases oppression of hemopoiesis against the background of chloramphenicol and ristomycin.

    Form release / dosage:Tablets 50 mg.
    Packaging:

    10 tablets per contour cell or cell-free packaging.

    For 250 contour non-jammed packages with an equal number of instructions for use are placed in a box of cardboard.

    3 or 5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    It is allowed to use contoured cell packs with an equal number of instructions for use in a cardboard box.

    Storage conditions:

    In a dry place protected from light.

    Keep out of the reach of children.

    Shelf life:

    4 years. Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N001149 / 01
    Date of registration:18.03.2008
    The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspMARBIOFARM, OJSCMARBIOFARM, OJSC
    Information update date: & nbsp12.11.2015
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