Furazolidone (Furazolidone)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceFurazolidoneFurazolidone
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  • Furazolidone
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    BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC     Republic of Belarus
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    AVEKSIMA, JSC     Russia
  • Furazolidone
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    MARBIOFARM, OJSC     Russia
    • Dosage form: & nbsppills
    Composition:

    one tablet contains 0.05 g of furazolidone and auxiliary substances: milk sugar, potato starch, aerosil, calcium stearate.

    Description:

    tablets of yellow or greenish-yellow color, flat-cylindrical, with a bevel.

    Pharmacotherapeutic group:antimicrobial and antiprotozoal.
    ATX: & nbsp

    G.01.A.X.06   Furazolidone

    Pharmacodynamics:

    The drug refers to antimicrobial and antiprotozoopyh means. Has bacteriostatic action against microbes. The mechanism of action is the violation of the activity of certain enzyme systems of bacteria. Spectrum of action: Gram-positive cocci (Streptococcus, Staphylococcus), gram-negative rods (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Of the causative agents of intestinal infections, the causative agents of dysentery, typhoid and paratyphoid are most sensitive. Sustainability develops slowly.

    Pharmacokinetics:

    When administered orally furazolidone slightly absorbed and inactivated in the intestine.Only about 5% of the drug is excreted in the urine in unchanged form or in the form of metabolites, while staining the urine in brown.

    Indications:

    • dysentery;

    • paragiphy;

    • food poisoning;

    • giardiasis.

    Contraindications:

    Pregnancy, lactation. Increased individual sensitivity to the group of nitrofurans. Terminal stage of chronic renal failure, deficiency of glucose-6-dehydrogenase, age up to 1 year.

    Dosing and Administration:

    Furazolidone designate inside.

    For the treatment of paratyphoid, dysentery, food toxic infections adults take 0.1-0.15 g after meals 4 times a day for 5-10 days (duration depends on the nature and severity of the pathological process). In the same doses furazolidone can be taken in cycles of 3-6 days (intervals - 3-4 days).

    Doses for children - 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    Furazolidone it is not recommended to appoint more than 10 days.

    In the treatment of giardiasis, adults take 0.1 grams of furazolidone 4 times a day, children - at a dose of 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    Higher daily doses for adults for oral administration: single dose - 0.2 g, daily - 0.8 g.

    Side effects:

    Perhaps the appearance of nausea, vomiting, decreased appetite; in some cases, allergic reactions may develop.

    To reduce side effects when using furazolidone it is recommended to take it before meals and drink the drug with plenty of liquid, if necessary, reduce the dose, prescribe antihistamines and B vitamins. If there are any side effects, stop using the drug.

    Interaction:

    Furazolidone is an inhibitor of monoamine oxidase; When it is used, the same precautions as with other monoamine oxidase inhibitors should be followed.

    Aminoglycosides and tetracyclines enhance the antimicrobial properties of furazolidone. It sensitizes the body to alcohol.

    Furazolidone increases oppression of hemopoiesis against the background of chloramphenicol and ristomycin.

    Form release / dosage:Tablets of 50 mg.
    Packaging:

    For 10, 20 or 25 tablets in contour squamous packaging.

    By 1, 2, 3, 4 or 5 contour cell packs together with instructions for use in the pack from cardboard.

    10 tablets in a contour gluten-free packaging.

    By 20, 50, 100, 1000 contour packs, together with an equal number of instructions for use, in a box of cardboard (for hospitals).

    Storage conditions:

    In dry, protected from light, out of reach of children, at a temperature of 4 to +30 ° C.

    Shelf life:

    3 years. The drug should be used before the date indicated on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000577
    Date of registration:10.06.2010
    The owner of the registration certificate:BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC BORISOVSKIY FACTORY OF MEDPREPARATES, OJSC Republic of Belarus
    Manufacturer: & nbsp
    Information update date: & nbsp12.11.2015
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