Active substanceFurazolidoneFurazolidone
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  • Furazolidone
    pills inwards 
    DALHIMFARM, OJSC     Russia
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    AVEKSIMA, JSC     Russia
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    MARBIOFARM, OJSC     Russia
  • Dosage form: & nbsppills
    Composition:

    Active substance: furazolidone (in terms of 100 % substance) 0.05 g

    Excipients: potato starch - 0.049 g, calcium stearate - 0.001 g

    Description:

    tablets of yellow or greenish-yellow color, planocylindrical with chamfer

    Pharmacotherapeutic group:antimicrobial and antiprotozoal drug-nitrofuran
    ATX: & nbsp

    G.01.A.X.06   Furazolidone

    Pharmacodynamics:

    Antimicrobial agent, derivative of nitrofurans. It is active against gram-positive and gram-negative microbes, Trichomonas spp., Giardia lamblia. Most sensitive to furazolidone Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi.

    Slightly affects the pathogens of purulent and anaerobic infection. Stability of microorganisms develops slowly. It blocks monoamine oxidase.

    Nitrofurans disrupt the processes of cellular respiration of microorganisms, inhibit the cycle of tricarboxylic acids (the Krebs cycle), and also inhibit other biochemical processes of microorganisms, as a result of which their shell or cytoplasmic membrane is destroyed.As a result of the action of nitrofurans, microorganisms produce fewer toxins, so that the improvement of the patient's general condition is possible even before the expressed suppression of microflora growth. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate the immune system of the body (increase the complement titer and the ability of leukocytes to phagocytose microorganisms).

    Pharmacokinetics:

    It is well absorbed by oral administration. Against the background of inflammation of the meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. Rapidly and extensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in the feces, where therapeutic concentrations are achieved against the causative agents of intestinal infections.

    Indications:
    • dysentery;

    • paratyphuses;

    • giardiasis;

    • food poisoning.

    Contraindications:

    Increased individual sensitivity to the group of nitrofurans. The terminal stage of chronic renal failure, pregnancy, the period of breastfeeding, children under 3 years (for this dosage form).

    Carefully:

    chronic renal failure, deficiency of glucose-6-phosphate dehydrogenase, liver and nervous system diseases.

    With renal insufficiency Furazolidone does not create therapeutic concentrations in the urine, is cumulated and can have toxic effects.


    Dosing and Administration:

    Furazolidone prescribe inside, after eating.

    In the treatment of paratyphoid, dysentery, food poisoning, adults - 100-150 mg 4 times a day for 5-10 days (duration depends on the nature and severity of the pathological process). In the same doses Furazolidone can be taken in cycles by 3-6 days (intervals of -3-4 days).

    Children from 3 years - 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    Furazolidone it is not recommended to appoint more than 10 days.

    In the treatment of giardiasis adults - 100 mg Furazolidon 4 times a day, children from 3 years in a dose of 10 mg / kg of body weight per day (the daily dose is divided into 3-4 doses).

    For adults: the highest single dose is 200 mg, the daily dose is 800 mg.

    Side effects:

    Decreased appetite, down to anorexia, nausea, vomiting, allergic reactions (skin rash, hyperemia and itching of the skin, angioedema).

    To reduce adverse reactions with Furazolidone, it is recommended to drink the drug with a large amount of liquid, if necessary, reduce the dose, prescribe antihistamines and B vitamins. If there are any side effects, stop using the drug.

    Overdose:

    Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity

    (polyneuritis).

    Treatment: cancellation of the drug, the intake of a large amount of fluid, symptomatic therapy, antihistamines, B vitamins.

    Interaction:

    Furazolidone in combination with ethanol can lead to the development of sulfide-like reactions.

    Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine - possibly a sharp increase in blood pressure.

    Aminoglycosides and tetracyclines enhance the antimicrobial properties of furazolidone. Furazolidone increases oppression of hemopoiesis against the background of chloramphenicol and ristomycin.

    Medicines alkalinizing urine (antacids containing calcium and magnesium, inhibitors of carbonhydraz, citrates, sodium hydrogen carbonate) reduce the effect, and acidifying (ammonium chloride, calcium chloride, hydrochloric acid, ascorbic acid, methionine) - increase the effect of furazolidone.

    Special instructions:

    In elderly people, it is necessary to use with caution, in connection with possible changes in kidney function (a dose reduction may be required).

    At the initial pathology of the liver, the risk of hepatotoxic action increases.

    Avoid the use of products containing tyramine (cheese, beer, wine, beans, smoked meat) and other vasoconstrictive amines, there is a risk of hypertensive crisis.

    The risk of peripheral polyneuropathies increases with anemia, diabetes, electrolyte balance disorders, hypovitaminosis B. For the purpose of prevention, the appointment of B vitamins is required.

    Effect on the ability to drive transp. cf. and fur:

    Data on the adverse effect of Furazolidone in the recommended doses on the ability to drive vehicles or work with mechanisms are not present.

    Form release / dosage:

    Tablets 50 mg.


    Packaging:

    For 10 tablets in a contour mesh package or in a contour non-jawed package.

    For 20 tablets in a can of polymer or in a can of polymer with the control of the first opening and a shock absorber.

    2 contour mesh packs together with instructions for use are placed in a pack of cardboard.
    Banks or contour non-jawed packages, together with an equal number of instructions for use, are placed in a group package.
    Storage conditions:

    In a dry place protected from light.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LS-001195
    Date of registration:24.08.2011
    The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspDALHIMFARM, OJSCDALHIMFARM, OJSC
    Information update date: & nbsp12.11.2015
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