Antimicrobial agent, derivative of nitrofurans. It is active against gram-positive and gram-negative microbes, Trichomonas spp., Giardia lamblia. Most sensitive to furazolidone Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi.
Slightly affects the pathogens of purulent and anaerobic infection. Stability of microorganisms develops slowly. It blocks monoamine oxidase.
Nitrofurans disrupt the processes of cellular respiration of microorganisms, inhibit the cycle of tricarboxylic acids (the Krebs cycle), and also inhibit other biochemical processes of microorganisms, as a result of which their shell or cytoplasmic membrane is destroyed.As a result of the action of nitrofurans, microorganisms produce fewer toxins, so that the improvement of the patient's general condition is possible even before the expressed suppression of microflora growth. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate the immune system of the body (increase the complement titer and the ability of leukocytes to phagocytose microorganisms).