Active substanceGentamicinGentamicin
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  • Dosage form: & nbspointment for external use
    Composition:Gentamycin sulfate 1 mg (in terms of gentamycin (active dry matter)), base: paraffin oil solid - 0, 025 g, vaseline - up to 1 g.
    Description:Ointment from white to yellow.
    Pharmacotherapeutic group:Antibiotic - aminoglycoside
    ATX: & nbsp

    J.01.G.B.03   Gentamicin

    Pharmacodynamics:

    Gentamicin is a bactericidal broad-spectrum antibiotic from the group of aminoglycosides. It binds to the 30S subunit of ribosomes and disrupts the protein synthesis, preventing the formation of a complex of transport and information RNA, with erroneous reading of the genetic code and the formation of non-functional proteins; polyribosomes split and lose the ability to synthesize protein (bacteriostasis).

    Highly effective against gram-negative aerobic bacteria: Escherichia coli, Shigella spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp. The drug is also active against Gram-positive aerobic cocci: Staphylococcus spp. (including those that are resistant to penicillin). The drug is resistant to: Neisseria meningitidis, Treponema pallidum, some strains of Streptococcus spp., Anaerobic microorganisms.

    Pharmacokinetics:With external application is almost not absorbed. From large areas of the skin surface, damaged (wound, burn) or covered with granulation tissue, the absorption is rapid.
    Indications:Bacterial infections of the skin and soft tissues caused by sensitive microflora: pyoderma, superficial folliculitis, furunculosis, paronychia, sycosis; infected: seborrheic dermatitis, ulcers (including varicose), wounds (including surgical, flaccid), burns (including plants), insect bites, "vulgar" acne; abscesses of the skin and cysts, secondary bacterial infection in fungal and viral skin infections.
    Contraindications:Hypersensitivity to gentamicin and other aminoglycosides; pregnancy.
    Carefully:If it is necessary to apply on extensive skin surfaces - neuritis of the auditory nerve, myasthenia gravis, parkinsonism, botulism, renal insufficiency (including severe chronic renal failure (CRF) with azotemia and uremia), neonatal period, preterm infants, elderly age, lactation period .
    Dosing and Administration:Outwardly. A thin layer of ointment is applied to the affected area 3-4 times a day. Ointment is used to treat infections of dry skin (including against a background of eczema or psoriasis). With extensive skin lesions, the daily dose of ointment should not exceed 200 g.The duration of treatment depends on the location, the severity of the infection and the condition of the patient.
    Side effects:Allergic reactions: local - skin rash, itching, skin hyperemia, burning sensation; rarely generalized - fever, angioedema, eosinophilia. When absorbed from extensive surfaces, it is possible to develop systemic effects characteristic of gentamicin (nausea, vomiting, anemia, leukopenia, nephrotoxic and neurotoxic effects, ototok-sichnost).
    Overdose:When applied to extensive areas of damaged skin, a decrease in neuromuscular conduction is possible.
    Interaction:

    When applied to large areas of damaged skin and at the same time:

    - antimiasthenic drugs - reduces their effectiveness

    - "loop" diuretics - the oto and nephrotoxicity of gentamicin increases

    - methoxyflurane, polymyxins for parenteral administration and other drugs that block neuromuscular transmission (halogenated hydrocarbons as a medicine for inhalation anesthesia, narcotic analgesics, transfusion of large amounts of blood with citrate preservatives) - the risk of nephrotoxic action increases.

    Special instructions:Treatment is carried out under the control of antibioticograms of the drug, because with prolonged use it is possible to develop resistance. In such cases, it is necessary to cancel treatment and begin appropriate therapy. When applied to large areas of the skin, consideration should be given to the possibility of resorptive action, especially in patients with CRF. If there is no therapeutic effect within 1 week, you should consult your doctor.
    Form release / dosage:Ointment for external use 0.1% by 10 or 15 g.
    Packaging:In tubes of aluminum. Each tube together with instructions for medical use of the drug is placed in a cardboard pack.
    Storage conditions:List B. Store at a temperature not exceeding 20 ° C. Keep out of the reach of children.
    Shelf life:3 years. Do not use the drug after the expiration date.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002262 / 01
    Date of registration:03.10.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.03.2017
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