Gentamicin - instructions for use, doses, side effects, contraindications

Excipients: sodium hydrogen phosphate to decahydrate 14.33 mg, sodium dihydrogen phosphate monohydrate 3.68 mg, sodium chloride 4.60 mg, benzalkonium chloride solution 50%, 0.20 mg, water purified to 1 ml.

Description:Transparent, colorless or colorless with a yellowish tinge of liquid.

Pharmacotherapeutic group:Antibiotic-aminoglycoside

ATX: & nbsp

J.01.G.B.03 Gentamicin

Pharmacodynamics:

Gentamicin is an antibiotic of the aminoglycoside group.

The mechanism of its action is a violation of the synthesis of bacterial proteins by binding to the 30S subunit of bacterial ribosomes. In this case, the formation of proteins with an inappropriate amino acid sequence. Gentamicin has a bactericidal effect in vitro against the following strains of bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes, Escherichia coli, Haemophilus influenza, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Serratia marcescens. Tormycin-resistant microorganisms are also resistant to the action of gentamicin (cross-resistance).

Pharmacokinetics:Absorption of gentamicin for local administration is negligible.

Indications:Bacterial infections of the eye caused by sensitive microflora - blepharitis, blepharoconjunctivitis, dacryocystitis, conjunctivitis, keratitis, keratoconjunctivitis, meibomitis, prevention of postoperative and post-traumatic infectious complications.

Contraindications:

- hypersensitivity to any of the components of the drug or to antibiotics of the aminoglycoside group;

- Children's age up to 1 year;

- Pregnancy;

- the period of lactation (breastfeeding);

- severe impairment of kidney function;

- neuritis of the auditory nerve;

- Myasthenia gravis.

Carefully:

Long-term local application of the drug may lead to a secondary bacterial and fungal infection.

In case of prolonged bacterial infection of the eyes, local treatment should be supplemented with the use of antibiotics of systemic action.

Pregnancy and lactation:

During pregnancy, the use of the drug is contraindicated.

When prescribing the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

Adults and children over 1 year old

With infectious lesions of the eyes of medium severity, 1 to 2 drops every 4 hours into the lower conjunctival sac; with severe lesions of 1-2 drops every hour. Duration of application no more than 14 days.

Side effects:

During the treatment may appear: lacrimation, red eyes, pain and burning in the eyes, photophobia.These symptoms can persist for several minutes after the instillation of the drug.

Long-term use in case of hypersensitivity to the components of the drug in single cases leads to the appearance of local allergic reactions, thrombocytopenic purpura, hallucinations.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, inform the doctor about it.

Overdose:There are no data on overdose with topical application of gentamicin.

Interaction:During the application of gentamycin sulfate in the form of eye drops, there is no clinically significant drug interaction, with the exception of cross-resistance with tobramycin.

Special instructions:Taking into account the content of benzalkonium chloride in the preparation, you should remove soft contact lenses before instillation and install them not earlier than 15 minutes after instillation. Benzalkonium chloride may cause eye irritation and change the color of contact lenses.

Effect on the ability to drive transp. cf. and fur:Due to possible blurring of vision after instillation, the drug should not be used before driving vehicles or working with mechanisms.

Form release / dosage:Eye drops 0,3%.

Packaging:5 ml are packed in a polyethylene bottle with a dropper, closed with a screw cap with a warranty ring. 1 bottle together with the instruction for use is placed in a cardboard box.

Storage conditions:

Store in a dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Shelf life after opening the bottle is 4 weeks.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N015940 / 01

Date of registration:18.11.2009 / 19.12.2011

Expiration Date:Unlimited

The owner of the registration certificate:Warsaw Pharmaceutical Plant Polfa, JSCWarsaw Pharmaceutical Plant Polfa, JSC Poland

Manufacturer: & nbsp

WARSAW PHARMACEUTICAL WORK POLFA, S.A. Poland

Representation: & nbspAKRIKHIN OJSC AKRIKHIN OJSC Russia

Information update date: & nbsp23.03.2017

Illustrated instructions

Instructions

Gentamicin (Gentamicin)