Active substanceGentamicinGentamicin
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  • Dosage form: & nbspeye drops
    Composition:

    Active substance: gentamycin sulfate (in terms of the active substance) 3.0 mg

    Excipients:

    disodium salt of ethylenediaminetetraacetic acid (sodium edetate) 0.3 mg

    Polyglucin (6% solution of a glucose-dextran polymer with a molecular weight of 50,000 to 70,000 with the addition of 0.9% sodium chloride) - 0.78 ml. Water for injection - up to 1.0 ml.

    Description:Transparent colorless or slightly yellowish liquid.
    Pharmacotherapeutic group:Antibiotic - aminoglycoside
    ATX: & nbsp

    J.01.G.B.03   Gentamicin

    Pharmacodynamics:

    Bactericidal broad-spectrum antibiotic from the group of aminoglycosides. It binds to the 30S subunit of the ribosomes and disrupts protein synthesis, preventing the formation of a complex of transport and information RNA, with erroneous reading of the genetic code and the formation of non-functional proteins; polyribosomes split and lose the ability to synthesize protein (bacteriostasis). Unlike other antibiotics, aminoglycosides have a bactericidal action - they reduce the barrier functions of cell membranes at high concentrations and cause the death of microorganisms.

    Effective against Staphylococcus spp.(coagulase-positive and coagulase-negative), Pseudomonas aeruginosa, Proteus spp. (including indolpositive and indolotricative strains), Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Enterobacter aerogenes, Moraxella lacunata, Neisseria spp. (including Neisseria gonorrhoeae).

    Pharmacokinetics:When topical application is absorbed in small amounts. Due to the low adsorption in the local application, it practically does not have systemic effects.
    Indications:Bacterial infections of the eye caused by sensitive microflora: blepharitis, blepharoconjunctivitis, dacryocystitis, conjunctivitis, keratitis, keratoconjunctivitis, meibomitis, internal barley, prevention of postoperative and post-traumatic complications.
    Contraindications:Hypersensitivity to the components of the drug or to the antibiotics of the aminoglycoside group, pregnancy, lactation, children under 1 year.
    Carefully:Severe violations of kidney function, neuritis of the auditory nerve, myasthenia gravis.
    Pregnancy and lactation:It is not recommended to use the drug during pregnancy. When prescribing the drug during lactation, breastfeeding should be discontinued.
    Dosing and Administration:Locally. The drug is instilled in a conjunctival sac of a damaged eye, 1-2 drops.With infectious lesions, eyes of medium severity are prescribed every 4 hours; with severe lesions - every hour. Duration of application - no more than 14 days.
    Side effects:

    After instillation, lacrimation, reddening of the eyes, pain, burning, photophobia, visual impairment for several minutes after instillation are possible.

    Perhaps the development of allergic reactions.

    Prolonged use of the drug in case of hypersensitivity to the components of the drug in a single case leads to the appearance of thrombocytopenic purpura, hallucinations.

    Overdose:Information on the toxic effect of gentamicin due to an overdose when it is applied topically is not available.
    Interaction:

    It is not recommended to use together with erythromycin and chloramphenicol because of pharmaceutical incompatibility.

    In the case of severe bacterial infection of the eye, local treatment should be supplemented with the general use of antibiotics, but it is not necessary to combine the use of eye drops of gentamicin with other antibiotics that exert oto and nephrotoxic effects.

    Special instructions:

    If there is no clinical effect for several days, you should consult your doctor.

    Long-term use of gentamicin may lead to the growth of non-susceptible microorganisms including. mushrooms.

    Before applying the drug, it is necessary to remove soft contact lenses. They can be re-dressed no earlier than 30 minutes after instillation.

    Effect on the ability to drive transp. cf. and fur:Due to possible blurring of vision after instillation, the drug should not be used before driving vehicles and performing potentially hazardous activities.
    Form release / dosage:Eye drops 0,3%.
    Packaging:

    By 5 or 10 ml in glass bottles, hermetically sealed with rubber stoppers, followed by rolling with aluminum caps or in polymer bottles-droppers.

    On 1 glass vial or on 1 polymeric flask-dropper together with the instruction on application in a pack from a cardboard. By 5 glass bottles or 5 polymer bottles-droppers in a contour acheive box along with instructions for use in a pack of cardboard.

    For hospitals

    By 5 glass bottles or 5 polymer bottles-droppers in a contour squamous packaging. For 10 contour mesh packages together with instructions for use in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 20 ° C.

    Keep out of the reach of children!

    Shelf life:

    2 years in unopened manufacturer packaging. After opening, the bottle should be used for 14 days.

    After the expiration date, the drug can not be used.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-002416
    Date of registration:11.05.2012 / 23.04.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:BRYNTSALOV-A, CJSC BRYNTSALOV-A, CJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp23.03.2017
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