Gentamycin-AKOS - instructions for use, dose, side effects, contraindications

Bactericidal broad-spectrum antibiotic from the group of aminoglycosides. It binds to the 30S ribosomal subunit and disrupts protein synthesis, preventing the formation of the complex transport and information ribonucleic acid, wherein occur an erroneous reading of the genetic code and the formation of non-functional proteins; polyribosomes split and lose the ability to synthesize protein (bacteriostasis). . Unlike other aminogliklozidy antibiotics have bactericidal action - in high concentrations decrease the barrier function of cell membranes and cause microbial death.

Highly effective against bacterial skin infections caused by Staphylococcus spp., Streptococcus spp., Proteus vulgaris, Escherichia coli, Pseudomonas aeriginosa, Enterobacter aerogenes.

Pharmacokinetics:With external application is almost not absorbed. From large areas of the skin surface, damaged (wound, burn) or covered with granulation tissue, the absorption is rapid.

Indications:

Bacterial infections of the skin and soft tissues, caused by a sensitive microflora - pyoderma (including gangrenous), superficial folliculitis, furunculosis, sycosis, paronychia.

Infected: dermatitis (including contact, seborrhoeic and eczematous), ulcers (including varicose), wounds (including surgical, flaccid), burns (including plants), insect bites, abscesses of the skin and cysts, "vulgar" acne; secondary bacterial infection in fungal and viral skin infections.

Contraindications:Hypersensitivity (including to other aminoglycosides in the anamnesis).

Carefully:

If it is necessary to apply on extensive skin surfaces - neuritis of the auditory nerve, myasthenia gravis, parkinsonism, botulism, renal failure (including severe chronic renal failure with azotemia and uremia), neonatal period, prematurity, elderly age, pregnancy, lactation.

Action category on the fetus. AT

Dosing and Administration:

Outwardly!

A thin layer of ointment is applied to the affected area 3-4 times a day. The course of treatment is 7-14 days. The duration of treatment is determined by the doctor. Ointment is used to treat infections of dry skin (incl.on a background of eczema or psoriasis)

If necessary, apply a bandage.

Side effects:

Allergic reactions: local - skin rash, itching, skin hyperemia, burning sensation; rarely generalized - fever, angioedema, eosinophilia.

When absorbed from extensive surfaces, it is possible to develop systemic effects.

Interaction:Simultaneously or immediately after the end of the course of treatment with Gentamicin (when applied on large surfaces and / or for a long time), antimicrobial and other drugs that have an otonephrotoxic effect should not be prescribed.

Special instructions:

Treatment is carried out under the control of antibioticograms of the drug, because with prolonged use it is possible to develop resistance. In such cases, treatment should be noted and appropriate therapy initiated.

When applied to large areas of the skin, consideration should be given to the possibility of resorptive action, especially in patients with chronic renal insufficiency.

If there is no therapeutic effect within 1 week, you should consult your doctor.

Form release / dosage:Ointment for external use 0,1%.

Packaging:

For 15 g in tubes are aluminum.

Each tube with instructions for use in a pack of cardboard.

Storage conditions:

List B. At a temperature of 8 ° C to 15 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002192 / 01

Date of registration:20.11.2008

Expiration Date:Unlimited

The owner of the registration certificate:SYNTHESIS, OJSC SYNTHESIS, OJSC Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Information update date: & nbsp23.03.2017

Illustrated instructions

Instructions

Gentamycin-AKOS (Gentamicin-AKOS)