Gentamicin - instructions for use, doses, side effects, contraindications

Disodium edetate (disodium ethylenediaminetetraacetic acid), sodium chloride, polyglucin - a solution of dextran with a molecular weight of 50,000 to 70,000 and sodium chloride, water for injection.

Description:Transparent colorless or slightly colored liquid.

Pharmacotherapeutic group:Antibiotic, aminoglycoside

ATX: & nbsp

J.01.G.B.03 Gentamicin

Pharmacodynamics:

Bactericidal broad-spectrum antibiotic from the group of aminoglycosides. It binds to the 30S subunit of ribosomes and disrupts protein synthesis, preventing the formation of a complex of transport and information RNA, with erroneous reading of RNA and the formation of non-functional proteins; polyribosomes split and lose the ability to synthesize protein (bacteriostasis). Unlike other antibiotics, aminoglycosides have a bactericidal effect - they reduce the barrier functions of cytoplasmic membranes at high concentrations and cause the death of microorganisms.

Effective against Staphylococcus spp. (coagulase-positive and coagulase-negative), Pseudomonas aeruginosa, Proteus spp. (incl.Indol-positive and Indo-negative strains), Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Enterobacter aerogenes (Aerobacter aerogenes), Moraxella lacunata, Neisseria spp. (including Neisseria gonorrhoeae).

Pharmacokinetics:When topical application is absorbed in small amounts.

Indications:The drug is used to treat bacterial infections of the eyes (blepharitis, blepharoconjunctivitis, conjunctivitis, keratoconjunctivitis, keratitis, dacryocystitis, meibomitis). Prevention of infectious complications after trauma and eye operations (for this purpose the drug is prescribed before and after surgery).

Contraindications:Gentamicin is contraindicated in case of hypersensitivity to all components of the drug.

Carefully:In severe violations of kidney function, neuritis of the auditory nerve.

Pregnancy and lactation:The drug should be given to pregnant women only if the intended benefit exceeds the risk of side effects in the fetus. The use of the drug during lactation is possible on the recommendation of a doctor.

Dosing and Administration:Locally. Buried in the conjunctival sac of the affected eye. For infectious lesions, eyes of medium severity are prescribed 1 drop every 4 hours; with severe lesions, 1 drop every 1 hour.Duration of application no more than 14 days.

Side effects:

After instillation of the drug, lacrimation, redness of the eyes, pain, burning, photophobia, and visual impairment are possible within a few minutes after instillation.

Perhaps the development of allergic reactions.

With prolonged use, there may be a fungal infection of the eyes or development of bacteria resistant to gentamicin.

Overdose:There is no evidence of overdose of gentamicin in its topical application.

Interaction:

It is not recommended to use together with erythromycin and chloramphenicol because of pharmaceutical incompatibility.

In case of severe bacterial infection of the eyes, local treatment should be supplemented with the general use of antibiotics, however, the use of eye drops should not be combined Gentamicin with other antibiotics that exert oto- and nephrotoxic action.

Special instructions:

Before using the drug, you must remove soft contact lenses. They can be re-laid no earlier than 30 minutes after instillation of the drug.

Insensitive microorganisms can develop on the background of treatment.In such cases, it is necessary to cancel treatment and begin appropriate therapy.

Form release / dosage:Eye drops 0,3%.

Packaging:

1.3 ml, 1.5 ml, 2 ml or 5 ml in a polymer polymer tube.

1, 2, 5 tube-droppers with instructions for the use of the drug and instructions for the use of a tube-dropper in a pack of cardboard with partitions or without partitions.

5 ml or 10 ml in the bottle-kapelyshtsy polymeric.

1.2 flask-kapelyshtsy with instructions for the use of the drug and instructions for the use of a bottle-kapelyshtsy in a pack of cardboard.

Storage conditions:List B. At temperatures not higher than 15 ° C, protected from light, out of reach of children.

Shelf life:

2 years, after opening a tube-dropper or a bottle-dropper - 1 month.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-001407

Date of registration:10.10.2011

Expiration Date:Unlimited

The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia

Manufacturer: & nbsp

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Information update date: & nbsp23.03.2017

Illustrated instructions

Instructions

Gentamicin (Gentamicin)