The most frequent undesirable effect in the treatment of Glybenklamidom is hypoglycemia. This condition can take a protracted character and contribute to the development of severe conditions up to a comatose, life-threatening patient or ending lethally. With diabetic polyneuropathy or with concomitant treatment with sympatholytic drugs (see section "Interaction with other drugs"), typical precursors of hypoglycemia may be mild or absent altogether.
The reasons for the development of hypoglycemia can be: drug overdose; lack of evidence for his appointment; irregular eating; elderly patients; vomiting; diarrhea; large physical exertion; diseases,reducing the need for insulin (violations of liver and kidney function, hypofunction of the adrenal cortex, pituitary gland or thyroid gland); alcohol abuse, as well as interaction with other drugs.
Symptoms of hypoglycemia are: a strong feeling of hunger, sudden profuse sweating, palpitations, pallor and a decrease in skin temperature, paresthesia of the oral mucosa, tremors, general anxiety, headache, pathological drowsiness, sleep disorders, feelings of fear, impaired coordination of movements, temporary neurologic disorders (eg, visual and speech disorders, manifestations of paresis and paralysis, or altered perception of sensations). With the progression of hypoglycemia, patients may lose self-control and consciousness, a predisposition to convulsions develops.
Along with hypoglycemia are possible:
On the part of the digestive system: rare nausea, eructation, vomiting, "metallic" taste in the mouth, a feeling of heaviness and fullness in the stomach, abdominal pain and diarrhea. In some cases, a temporary increase in the activity of "hepatic" enzymes (glutamino-oxaloacetic aminotransferase, glutamino-pyruvic aminotransaminase, alkaline phosphatase) in the blood serum, drug-induced hepatitis and jaundice.
Skin allergic reactions: Rare, itchy skin, urticaria, redness of the skin, Quincke's edema, pinpoint bleeding to the skin, flaky rash on large skin surfaces and photosensitivity can rarely occur. Very rarely skin reactions can serve as the beginning of the development of severe conditions, accompanied by shortness of breath and lowering blood pressure until the onset of shock, threatening the life of the patient. Separate cases of severe generalized allergic reactions with skin rash, pain in the joints, fever, the appearance of protein in the urine and jaundice are described.
On the part of the system of hemopoiesis: rarely there is thrombocytopenia or very rarely leukocytopenia, agranulocytosis. In isolated cases, hemolytic anemia or pancytopenia develops.
Other side effects observed in isolated cases include a mild diuretic effect, the temporary appearance of a protein in the urine, impaired vision and accommodation, as well as an acute reaction of alcohol intolerance after its use,expressed by complications from the circulatory and respiratory organs (disulfiram-like reaction: vomiting, sensation of fever in the face and upper body, tachycardia, dizziness, headache).
If any side effects occur, tell your doctor.