Gopantam - instructions for use, dose, side effects, contraindications

Active substance:
Calcium Gopantate	250 mg	500 mg
Excipients:
magnesium carbonate (magnesium carbonate basic)	33.0 mg	66.0 mg
talc	3.0 mg	6.0 mg
calcium stearate	9.0 mg	18.0 mg
methyl cellulose	15.0 mg	30.0 mg
Weight of a tablet:	0.31 g	0.62 g

Description:

Tablets are white, flat-cylindrical with a risk on one side and a facet on both sides.

Pharmacotherapeutic group:Nootropic remedy

ATX: & nbsp

N.06.B.X Other psychostimulants and nootropic drugs

Pharmacodynamics:

The effect of Hepantam® is related to the presence of gamma-aminobutyric acid in the structure and its direct effect on GABA_at-receptor-channel complex. The drug has nootropic and anticonvulsant action.It increases the resistance of the brain to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines moderate sedation with a mild stimulating effect, reduces motor excitability, activates mental and physical performance.

Improves the metabolism of gamma-aminobutyric acid in chronic alcohol intoxication and subsequent abolition of ethanol.

It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.

Pharmacokinetics:

After oral administration, it is rapidly absorbed in the gastrointestinal tract. The greatest concentrations are created in the liver, kidneys, in the wall of the stomach and skin. Penetrates through the blood-brain barrier. It is not metabolized. It is unchanged for 48 hours: 67.5% of the dose taken with urine, 28.5% with feces.

Indications:

- Cognitive impairment of organic brain lesions, including those with consequences of neuroinfections, craniocerebral trauma and neurotic disorders;

- with extrapyramidal hyperkinesias, in patients with hereditary diseases of the nervous system in combination with the therapy;

- as a corrector for side effects of neuroleptics, with neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy for cerebral insufficiency in patients with schizophrenia;

- epilepsy with retardation of mental processes in complex therapy with anticonvulsants;

- psycho-emotional overload, decreased mental and physical performance, to improve concentration and memorization;

- neurogenic disorders of urination (pollakiuria, imperative urges, mandatory urinary incontinence, enuresis);

- children with developmental delay (mental, speech, motor, or their combination), including against the background of perinatal encephalopathy and in children with various forms of infantile cerebral palsy;

- children with hyperkinetic disorders (attention deficit hyperactivity syndrome);

- children with neurosis-like conditions (tics, with stuttering, mainly with clonic form).

Contraindications:

Hypersensitivity, acute severe kidney disease, pregnancy and the period of breastfeeding.

Pregnancy and lactation:The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:

Inside, 15-30 minutes after eating.

Single dose for adults usually is 250-1000 mg, for children - 250-500 mg; daily intake for adults - from 1500 mg to 3000 mg, for children - from 750 mg to 3000 mg. The course of treatment is from 1 to 4 months, in some cases up to 6 months. After 3-6 months, a repeat course of treatment is possible.

In cases of cognitive impairment with organic brain lesions, including those with consequences of neuroinfections, craniocerebral trauma and neurotic disorders: 250 mg 3-4 times a day.

When extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with ongoing therapy: in a dose of 500 mg to 3000 mg per day. The course of treatment - up to 4 or more months.

As a corrector for side effects of neuroleptic drugs, with a neuroleptic exstpapiramid syndrome (hyperkinetic and akinetic), as part of complex therapy for cerebral organic insufficiency in patients with schizophrenia: adults - in a dose from 500 mg to 1000 mg 3 times a day; children - in a dose of 250 mg to 500 mg 3-4 times a day. The course of treatment is 1-3 months.

With epilepsy with the slowing down of mental processes in complex therapy with anticonvulsants: adults - in a dose from 500 mg to 1000 mg 3 times a day; children - in a dose of 250 mg to 500 mg 3-4 times a day. The course of treatment is up to 6 months.

At psycho-emotional overload, reduction of mental and physical working capacity, for improvement of concentration and rememberingI: 250 mg 3 times a day.

With neurogenic disorders of urination: adults - in a dose from 500 mg to 1000 mg 2-3 times a day; children - in a dose of 250 mg to 500 mg 3 times a day (the daily dose is 25-50 mg / kg). The course of treatment is 1-3 months.

Children with various pathologies of the nervous system depending on the age of the drug is recommended in a dose of 1000-3000 mg per day.

Tactics of prescribing the drug: increasing the dose for 7-12 days, taking in the maximum dose for 15-40 days and gradually reducing the dose before lifting Hopantam® within 7-8 days. The break between the course of Hopantama®, as well as for any other nootropic remedy, is from 1 to 3 months.

Children with developmental delay: 500 mg 3-4 times a day. The course of treatment is 2-3 months.

Children with attention deficit hyperactivity disorder: depending on the body weight, the drug is prescribed at an average therapeutic dose of 30 mg / kg per day, morning and afternoon. The optimum dose is determined for each patient individually by selection with a gradual increase in dose during the first 5-7 days. The course of treatment is 3-4 months.

Children with neurosis-like conditions (tics: with stuttering, predominantly in the clonic form): in a dose from 250 mg to 500 mg 3-6 times a day. The course of treatment is 1-4 months.

Taking into account the nootropic effect of the drug, it is preferably taken in the morning and afternoon (up to 17 hours).

The drug is used in children older than 3 years. At an earlier age, it is recommended that the drug be taken in a pediatric form.

Side effects:

Allergic reactions are possible (rhinitis, conjunctivitis, skin allergic reactions). In this case, cancel the drug.

There are undesirable reactions from the CNS (hyperexcitation, sleep disturbance or drowsiness, lethargy, inhibition, headache, dizziness, noise in the head). In this case, reduce the dose of the drug.

Overdose:

Increased severity of dose-related side effects (sleep disturbance or drowsiness, noise in the head).

Treatment: Activated carbon, gastric lavage, symptomatic therapy.

Interaction:

Prolongs the effect of barbiturates, enhances the action of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, neuroleptics.

Potentsiruet action of local anesthetics (procaine).

Action of Hepantam^® is enhanced in combination with glycine, etidronic acid.

Special instructions:In the conditions of long-term treatment, simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

Effect on the ability to drive transp. cf. and fur:

In the first days of taking the drug should be careful when driving vehicles and mechanisms, given the possible occurrence of drowsiness (see section "Side effect").

Form release / dosage:

Tablets, 250 mg and 500 mg.

Packaging:

For 50 tablets (for a dosage of 500 mg) or 100 tablets (for a dosage of 250 mg) in cans of polymeric or 10 tablets in contour cell packs.

Each jar or 3, 5 contour squares, together with the instruction for use, is placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

4 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N003112 / 01

Date of registration:29.01.2009 / 16.10.2015

Expiration Date:Unlimited

The owner of the registration certificate:ALTAYVITAMINS, CJSC ALTAYVITAMINS, CJSC Russia

Manufacturer: & nbsp

ALTAYVITAMINS, CJSC Russia

Representation: & nbspALTAYVITAMINS, CJSCALTAYVITAMINS, CJSC

Information update date: & nbsp05.05.2017

Illustrated instructions

Instructions

Hopantam® (Gopantam®)