Pantogam® (Pantogam®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHopantenic acidHopantenic acid
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    • Dosage form: & nbsppills
    Composition:

    For one tablet:

    active substance: calcium gopantenate (Pantogam®) 250 mg;

    Excipients: methylcellulose 0.8 mg, calcium stearate 3.1 mg, magnesium hydroxycarbonate 46.8 mg, talc 9.3 mg.

    Description:Tablets of white color, flat-cylindrical, with a facet and a risk.
    Pharmacotherapeutic group:nootropic remedy
    ATX: & nbsp

    N.06.B.X   Other psychostimulants and nootropic drugs

    Pharmacodynamics:

    The spectrum of action of Pantogam® is related to the presence of structure of gamma-aminobutyric acid. Mechanism action is due direct influence of Pantogam® on GABAat-receptor-channel complex.

    The drug has nootropic and anticonvulsant action.Pantogam® improves brain resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines moderate sedation with mild stimulating effect, reduces motor excitability, activates mental and physical performance. It improves the metabolism of GABA in chronic alcohol intoxication and after the abolition of ethanol. It is able to inhibit the acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, thereby prolonging the action of the latter. It causes inhibition of the pathologically increased vesicle reflex and detrusor tone.
    Pharmacokinetics:

    Pantogam® is rapidly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, in the wall of the stomach and skin. The drug is not metabolized and is excreted unchanged for 48 hours: 67.5% of the dose taken with urine, 28.5% with feces.

    Indications:

    - Cognitive impairment in organic brain lesions (including the effects of neuroinfections and craniocerebral trauma) and neurotic disorders;

    - schizophrenia with cerebral organic insufficiency;

    - cerebrovascular insufficiency, caused by atherosclerotic changes in cerebral vessels;

    - extrapyramidal disorders (myoclonus epilepsy, Huntington's chorea, hepatolenticular degeneration, Parkinson's disease, etc.), as well as for the treatment and prevention of extrapyramidal syndrome (hyperkinetic and akinetic) - caused by the intake of neuroleptics;

    - epilepsy with the slowing down of mental processes in the complex therapy with anticonvulsants;

    - psycho-emotional overload, reduction of mental and physical working capacity, to improve concentration, and memorization;

    - neurogenic disorders of urination (pollakiuria, imperative urges, mandatory urinary incontinence, enuresis);

    - children with perinatal encephalopathy, mental retardation of varying severity, with developmental delay (mental, speech, motor or combination), with various forms of infantile cerebral palsy, hyperkinetic disorders (attention deficit hyperactivity disorder), neurosis-like conditions (stuttering, mainly clonic form, tics).

    The drug is used in children older than 3 years. At an earlier age, it is recommended to take the drug in the form of a syrup.

    Contraindications:

    - Hypersensitivity;

    - Acute severe kidney disease;

    - Pregnancy, lactation.

    Dosing and Administration:

    Inside 15-30 minutes after eating.

    Single dose for adults is usually 0.25-1 g, for children - 0.25-0.5 g; daily intake for adults - 1.5-3 g, for children - 0,75-3 g. The course of treatment - from 1 to 4 months, in some cases - up to 6 months. After 3-6 months, a repeat course of treatment is possible.

    With epilepsy in combination with anticonvulsants in a dose of 0.75 to 1 g per day. The course of treatment is up to 1 year and more.

    With extrapyramidal neuroleptic syndrome in combination with daily therapy up to 3 g, treatment for several months.

    With extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with ongoing therapy from 0.5 to 3 grams per day. The course of treatment up to 4 months or more.

    At the consequences of neuroinfections and craniocerebral injuries 0.25 g 3-4 times a day.

    To restore working capacity under increased loads and asthenic conditions Pantogam® is prescribed 0.25 g three times a day.

    For the treatment of extrapyramidal syndrome caused by the administration of neuroleptics: adults 0.5-1 g 3 times a day, children - 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

    With ticks: children 0.25-0.5 g 3-6 times a day, for 1-4 months.

    In cases of urination disorders: adults 0.5-1 g 2-3 times a day, children 0.25-0.5 g (daily dose is 25-50 mg / kg). The course of treatment is from 1 to 3 months.

    Children with various pathologies of the nervous system depending on the age of the drug is recommended in a dose of 1-3 g. Tactics of the drug: a dose increase for 7-12 days, reception at the maximum dose for 15-40 days and a gradual dose reduction until Pantogam® is canceled within 7-8 days . The break between the exchange rates of Pantogam®, as well as for any other nootropic remedy, is from 1 to 3 months.

    In the conditions of long-term treatment, simultaneous administration of the drug with other nootropic and stimulating agents is not recommended.

    Given the nootropic effect of the drug, it is preferably administered in the morning and afternoon.

    Side effects:

    Allergic reactions are possible (rhinitis, conjunctivitis, skin allergic reactions). In this case, cancel the drug.

    Very rarely unwanted reactions from the CNS (hyperexcitation, sleep disturbance or drowsiness, lethargy, inhibition, headache, dizziness, noise in the head). In this case, reduce the dose of the drug.

    Overdose:

    Increased symptoms of side effects (sleep disorders or drowsiness, noise in the head).

    Treatment: Activated carbon, gastric lavage, symptomatic therapy.
    Interaction:

    Prolongs the effect of barbiturates, enhances the action of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, neuroleptics.

    The effect of Pantogam® is enhanced in combination with glycine, etidronic acid.

    Potentsiruet action of local anesthetics (procaine).

    Form release / dosage:Tablets, 250 mg.
    Packaging:

    10 tablets per contour cell packaging made of polyvinylchloride film and aluminum foil.

    5 contour mesh packages together with the instruction for use are placed in a pack of cardboard.

    Storage conditions:

    In a dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:LS-000339
    Date of registration:13.04.2010
    The owner of the registration certificate:PIK-PHARMA, LLC PIK-PHARMA, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspPIK-PHARMA LLC PIK-PHARMA LLC Russia
    Information update date: & nbsp23.12.2015
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